Impact of cigarette smoking on impaired insulin secretion and insulin resistance in Japanese men: The Saku Study.
Impact of cigarette smoking on impaired insulin secretion and insulin resistance in Japanese men: The Saku Study.
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DOI：
10.1111/jdi.12019
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发表时间：
2013-05-06
影响因子：
3.2
通讯作者：
Watanabe S
中科院分区：
文献类型：
--
作者：
Morimoto A;Tatsumi Y;Deura K;Mizuno S;Ohno Y;Watanabe S
评估吸烟对日本男性胰岛素分泌受损和胰岛素抵抗的影响。这项研究包括1199名年龄在30-79岁之间的男性，他们在2006年4月至2007年3月期间在Saku中心医院接受了全面的体检，在基线水平上没有糖尿病、胰岛素分泌受损和胰岛素抵抗。吸烟状况分为当前吸烟者、曾经吸烟者和从不吸烟者。胰岛素生成指数和稳态模型评估-胰岛素抵抗采用标准的75g口服葡萄糖耐量试验进行测定。日本糖尿病协会的标准被用来定义胰岛素分泌受损和胰岛素抵抗。参与者接受了跟踪调查，直到2011年3月。在3403和4092人年的随访中，分别有449名和99名男性出现了胰岛素分泌受损和胰岛素抵抗。在调整了年龄、糖尿病家族史、饮酒、运动、收缩压、甘油三酯、γ-谷氨酰转移酶、腰围、白细胞计数、吸烟状况的改变后，胰岛素分泌受损的多变量调整危险比(HR)在戒烟者和不吸烟者中分别为1.06(95%可信区间0.84~1.33)和1.95(95%可信区间1.44~2.63)。服药年数与胰岛素分泌受损的风险呈剂量依赖性正相关(Trend<；0.001的P值)。与非吸烟者相比，戒烟者胰岛素抵抗的多变量调整比为0.95(95%可信区间0.56~1.61)，现吸烟者为1.11(95%可信区间0.67~1.79)。吸烟是胰岛素分泌受损的一个可改变的危险因素。这一发现可能对其他亚洲人群也很重要，因为他们的胰岛素分泌能力较低。
To assess the impact of smoking on impaired insulin secretion and insulin resistance in Japanese men. This study included 1,199 men aged 30–79 years without diabetes, impaired insulin secretion and insulin resistance at baseline who underwent a comprehensive medical check‐up between April 2006 and March 2007 at Saku Central Hospital. Smoking status was categorized as current, ex‐smoker and never‐smoker. Insulinogenic index and homeostasis model assessment‐insulin resistance were determined using a standard 75‐g oral glucose tolerance test. The Japan Diabetes Society criteria were used to define impaired insulin secretion and insulin resistance. Participants were followed up until March 2011. A total of 449 and 99 men developed impaired insulin secretion and insulin resistance during 3,403 and 4,092 person‐years follow up, respectively. The multivariable‐adjusted hazard ratios (HRs) for impaired insulin secretion were 1.06 (95% confidence interval [CI] 0.84–1.33) in ex‐smokers and 1.95 (95% CI 1.44–2.63) in current smokers compared with never‐smokers after adjustment for age, familial history of diabetes, alcohol consumption, exercise, systolic blood pressure, triglyceride, γ‐glutamyltransferase, waist circumference, leukocyte count, changes in smoking status and changes in waist circumference. The number of pack‐years was positively associated with the risk for impaired insulin secretion in a dose‐dependent manner (P‐values for trend <0.001). The multivariable‐adjusted HRs for insulin resistance were 0.95 (95% CI 0.56–1.61) in ex‐smokers and 1.11 (95% CI 0.67–1.79) in current smokers compared with never‐smokers. Cigarette smoking is a modifiable risk factor for impaired insulin secretion. The findings might also be important for other Asian populations, which have low insulin secreting ability.
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