miR221/222 in cancer: their role in tumor progression and response to therapy.
miR221/222 in cancer: their role in tumor progression and response to therapy.
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DOI：
10.2174/156652412798376170
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发表时间：
2012-01
影响因子：
2.5
通讯作者：
Condorelli G
中科院分区：
文献类型：
--
作者：
Garofalo M;Quintavalle C;Romano G;Croce CM;Condorelli G
mirna是约24 nt的小非编码rna，可以阻断mRNA的翻译和/或负向调节其稳定性。有大量证据表明，mirna的失调是癌症的一个标志。mirna经常异常表达，其功能与参与细胞信号通路的癌基因和/或肿瘤抑制基因的调控有关。MiR-221和miR-222是两个高度同源的microrna，其上调最近在几种类型的人类肿瘤中被描述。MiR-221/222被认为是癌基因或肿瘤抑制基因，这取决于肿瘤系统。基于癌细胞中下调的mirna的重新表达，沉默肿瘤细胞或基因治疗方法可能代表一种新的抗肿瘤综合癌症治疗方法。在这里，我们将回顾miR-221/222在癌症进展中的作用及其作为癌症预后和治疗工具的用途。
MiRNAs are small non-coding RNAs of ~24 nt that can block mRNA translation and/or negatively regulate its stability. There is a large body of evidence that dysregulation of miRNAs is a hallmark of cancer. miRNAs are often aberrantly expressed and their function is linked to the regulation of oncogenes and/or tumor suppressor genes involved in cell signaling pathway. MiR-221 and miR-222 are two highly homologous microRNAs, whose upregulation has been recently described in several types of human tumors. MiR-221/222 have been considered to act as oncogenes or tumor suppressors, depending on tumor system. Silencing oncomiRs or gene therapy approaches, based on re-expression of miRNAs that are down-regulated in cancer cells, could represent a novel anti-tumor approach for integrated cancer therapy. Here we will review the role of miR-221/222 in cancer progression and their use as prognostic and therapeutic tools in cancer.
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影响因子：
21.3
作者：
Leevers, SJ
通讯作者：
Leevers, SJ
影响因子：
11.2
作者：
Kozaki, Ken-ichi;Imoto, Issei;Inazawa, Johji
通讯作者：
Inazawa, Johji
影响因子：
50.3
作者：
Garofalo M;Di Leva G;Romano G;Nuovo G;Suh SS;Ngankeu A;Taccioli C;Pichiorri F;Alder H;Secchiero P;Gasparini P;Gonelli A;Costinean S;Acunzo M;Condorelli G;Croce CM
通讯作者：
Croce CM
影响因子：
2.8
作者：
Fu, Xinhui;Wang, Qian;Chen, Lianzhou
通讯作者：
Chen, Lianzhou
DOI：
10.1073/pnas.0404432101
发表时间：
2004-08-10
影响因子：
11.1
作者：
Calin, GA;Liu, CG;Croce, CM
通讯作者：
Croce, CM