Changing patterns of SARS-CoV-2 infection through Delta and Omicron waves by vaccination status, previous infection and neighbourhood deprivation: a cohort analysis of 2.7 M people.
Changing patterns of SARS-CoV-2 infection through Delta and Omicron waves by vaccination status, previous infection and neighbourhood deprivation: a cohort analysis of 2.7 M people.
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DOI：
10.1186/s12879-022-07878-2
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发表时间：
2022-11-26
影响因子：
3.7
通讯作者：
Buchan, Iain
中科院分区：
文献类型：
--
作者：
Green, Mark A.;Hungerford, Daniel J.;Hughes, David M.;Garcia-Finana, Marta;Turtle, Lance;Cheyne, Christopher;Ashton, Matthew;Leeming, Gary;Semple, Malcolm G.;Singleton, Alex;Buchan, Iain
我们的研究考察了 SARS-CoV-2 感染是否因疫苗接种状况、个体之前是否检测呈阳性以及 SARS-CoV-2 Delta 和 Omicron 流行浪潮中的社区社会经济剥夺而有所不同。 使用英国柴郡和默西塞德郡 270 万居民的电子健康记录进行人口队列研究（2021 年 6 月 3 日至 2022 年 3 月 1 日）。我们的结果变量被登记为 SARS-CoV-2 检测呈阳性。解释变量是疫苗接种状况、之前登记的阳性检测结果和社区社会经济剥夺。 Cox 回归模型用于分析关联性。从 2021 年 9 月 1 日起，社会经济最贫困社区的 SARS-CoV-2 发病率原本较高，但从 2021 年 9 月 1 日起，最贫困社区的 SARS-CoV-2 发病率变得较高，并且在 Omicron 浪潮期间并不一致。完全接种疫苗（两剂）的个体与较少的登记阳性检测相关（例如，在 2021 年 9 月 1 日至 11 月 27 日期间进行检测的个体 — 风险比 (HR) = 0.48，95% 置信区间 (CI) = 0.47–0.50。之前登记为阳性检测的个体也不太可能进行登记阳性检测（例如，在 2021 年 9 月 1 日至 11 月 27 日期间进行测试的个人 —HR = 0.16，95% CIs = 0.15–0.18。然而，Omicron 时期的疫苗接种状况和之前登记的阳性检测的影响较小。Delta 和 Omicron 波期间 SARS-CoV-2 感染模式的变化揭示了一种动态的流行病，这种流行病继续以有时意想不到的方式影响不同的社区。在线版本包含可在 10.1186/s12879-022-07878-2 获取的补充材料。
Our study examines if SARS-CoV-2 infections varied by vaccination status, if an individual had previously tested positive and by neighbourhood socioeconomic deprivation across the Delta and Omicron epidemic waves of SARS-CoV-2. Population cohort study using electronic health records for 2.7 M residents in Cheshire and Merseyside, England (3rd June 2021 to 1st March 2022). Our outcome variable was registered positive test for SARS-CoV-2. Explanatory variables were vaccination status, previous registered positive test and neighbourhood socioeconomic deprivation. Cox regression models were used to analyse associations. Originally higher SARS-CoV-2 rates in the most socioeconomically deprived neighbourhoods changed to being higher in the least deprived neighbourhoods from the 1st September 2021, and were inconsistent during the Omicron wave. Individuals who were fully vaccinated (two doses) were associated with fewer registered positive tests (e.g., individuals engaged in testing between 1st September and 27th November 2021—Hazards Ratio (HR) = 0.48, 95% Confidence Intervals (CIs) = 0.47–0.50. Individuals with a previous registered positive test were also less likely to have a registered positive test (e.g., individuals engaged in testing between 1st September and 27th November 2021—HR = 0.16, 95% CIs = 0.15–0.18. However, the Omicron period saw smaller effect sizes for both vaccination status and previous registered positive test. Changing patterns of SARS-CoV-2 infections during the Delta and Omicron waves reveals a dynamic pandemic that continues to affect diverse communities in sometimes unexpected ways. The online version contains supplementary material available at 10.1186/s12879-022-07878-2.
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DOI：
10.1038/s41577-021-00592-1
发表时间：
2021-10
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Tregoning JS;Flight KE;Higham SL;Wang Z;Pierce BF
通讯作者：
Pierce BF
DOI：
10.1056/nejmoa2119451
发表时间：
2022-04-21
期刊：
The New England journal of medicine
影响因子：
--
作者：
Andrews N;Stowe J;Kirsebom F;Toffa S;Rickeard T;Gallagher E;Gower C;Kall M;Groves N;O'Connell AM;Simons D;Blomquist PB;Zaidi A;Nash S;Iwani Binti Abdul Aziz N;Thelwall S;Dabrera G;Myers R;Amirthalingam G;Gharbia S;Barrett JC;Elson R;Ladhani SN;Ferguson N;Zambon M;Campbell CNJ;Brown K;Hopkins S;Chand M;Ramsay M;Lopez Bernal J
通讯作者：
Lopez Bernal J
DOI：
10.1016/s0140-6736(22)00462-7
发表时间：
2022-04-02
期刊：
Lancet (London, England)
影响因子：
--
作者：
Nyberg T;Ferguson NM;Nash SG;Webster HH;Flaxman S;Andrews N;Hinsley W;Bernal JL;Kall M;Bhatt S;Blomquist P;Zaidi A;Volz E;Aziz NA;Harman K;Funk S;Abbott S;COVID-19 Genomics UK (COG-UK) consortium;Hope R;Charlett A;Chand M;Ghani AC;Seaman SR;Dabrera G;De Angelis D;Presanis AM;Thelwall S
通讯作者：
Thelwall S
DOI：
10.1068/a3692
发表时间：
2003-07-01
期刊：
ENVIRONMENT AND PLANNING A
影响因子：
--
作者：
Dorling, D;Rees, P
通讯作者：
Rees, P
影响因子：
3.7
作者：
Smith LE;Mottershaw AL;Egan M;Waller J;Marteau TM;Rubin GJ
通讯作者：
Rubin GJ