Coronary artery outcomes among children with Kawasaki disease in the United States and Japan.
Coronary artery outcomes among children with Kawasaki disease in the United States and Japan.
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DOI：
10.1016/j.ijcard.2013.06.027
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发表时间：
2013-10-09
影响因子：
3.5
通讯作者：
Burns, Jane C.
中科院分区：
文献类型：
--
作者：
Ogata, Shohei;Tremoulet, Adriana H.;Sato, Yuichiro;Ueda, Kayla;Shimizu, Chisato;Sun, Xiaoying;Jain, Sonia;Silverstein, Laura;Baker, Annette L.;Tanaka, Noboru;Ogihara, Yoshihito;Ikehara, Satoshi;Takatsuki, Shinichi;Sakamoto, Naoko;Kobayashi, Tohru;Fuse, Shigeto;Matsubara, Tomoyo;Ishii, Masahiro;Saji, Tsutomu;Newburger, Jane W.;Burns, Jane C.
据报道，日本川崎病(KD)患者的动脉瘤发生率低于美国。然而，由于对冠状动脉(CA)异常的定义不同，很难比较两国之间的冠状动脉(CA)预后。因此，我们使用标准定义和方法比较了日本和美国KD患者的CA内径。我们回顾了来自美国2个中心和日本3个中心的1082名KD患者的CA结果，并比较了发病后12周内获得的Z-max评分(左前降支或右冠状动脉最大内径以标准差单位表示)，并使用加拿大(Dallaire)和日本(FUSE)两种不同的回归方程进行计算。我们定义Z-max为-lt；2.5为正常，Z-max为≥10为巨大动脉瘤。美国和日本受试者的Z-max中位数分别为1.9SD单位和2.3SD单位(p<；0.001)。Z-max≥5.0%的患病率在两国间无显著差异。在对年龄、性别和治疗反应进行调整的多变量模型中，日本人仍然与较高的Z-max得分相关。此前报道的日本和美国之间的动脉瘤发病率差异可能是由于使用了不同的定义和命名方法。采用Z-Score作为报告CA内径的标准，将允许在不同国家之间进行有意义的比较，并将促进国际合作临床试验。
It has been claimed that the aneurysm rate for Kawasaki disease (KD) patients in Japan is lower than in the U.S. However it has been difficult to compare coronary artery (CA) outcomes between the two countries because of different definitions for CA abnormalities. Therefore, we compared CA internal diameters between Japanese and U.S. KD patients using standard definitions and methods. We retrospectively reviewed CA outcomes in 1082 KD patients from 2 centers in the U.S. and 3 centers in Japan and compared Z-max scores (maximum internal diameter for the left anterior descending or right coronary artery expressed as standard deviation units from the mean (Z-score) normalized for body surface area) obtained within 12 weeks after onset and calculated using two different regression equations from Canada (Dallaire) and Japan (Fuse). We defined a Z-max of <2.5 as normal and a Z-max of ≥ 10 as giant aneurysm. The median Z-max for the U.S. and Japanese subjects was 1.9 and 2.3 SD units, respectively (p<0.001). There was no significant difference in rates of patients with Z-max ≥ 5.0 between the countries. In a multivariable model adjusting for age, sex, and treatment response, being Japanese was still associated with a higher Z-max score. Previously reported differences in aneurysm rates between Japan and the U.S. likely resulted from use of different definitions and nomenclature. Adoption of Z-scores as a standard for reporting CA internal diameters will allow meaningful comparisons among different countries and will facilitate international, collaborative clinical trials.
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影响因子：
3.6
作者：
Belay, ED;Maddox, RA;Schonberger, LB
通讯作者：
Schonberger, LB
影响因子：
2
作者：
COLE, TJ;GREEN, PJ
通讯作者：
GREEN, PJ
DOI：
10.1016/j.echo.2010.10.015
发表时间：
2011-01-01
影响因子：
6.5
作者：
Margossian, Renee;Lu, Minmin;Colan, Steven D.
通讯作者：
Colan, Steven D.
影响因子：
5.2
作者：
Singh, Surjit;Aulakh, Roosy;Burns, Jane C.
通讯作者：
Burns, Jane C.
影响因子：
1.6
作者：
Manlhiot, Cedric;Millar, Kyle;McCrindle, Brian W.
通讯作者：
McCrindle, Brian W.