Immunomodulation in sepsis: the role of endotoxin removal by polymyxin B-immobilized cartridge.
Immunomodulation in sepsis: the role of endotoxin removal by polymyxin B-immobilized cartridge.
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DOI：
10.1155/2013/507539
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发表时间：
2013
影响因子：
4.6
通讯作者：
Artigas A
中科院分区：
文献类型：
--
作者：
Esteban E;Ferrer R;Alsina L;Artigas A
严重的脓毒症导致很高的发病率和死亡率。免疫调节策略可能是治疗脓毒症的一种辅助疗法。内毒素是革兰氏阴性菌的一种成分，被免疫细胞识别后在感染性休克的发病机制中发挥重要作用。清除内毒素可能是治疗脓毒症的有效辅助方法。吸附内毒素或炎性细胞因子的装置已被设计为治疗严重脓毒症的一种策略，特别是由革兰氏阴性菌引起的脓毒症。多粘菌素B固定化小柱已成功用于治疗腹源性脓毒症患者。虽然这种药盒被设想为吸附内毒素，但其他几种免疫学机制已经被阐明，而且这种装置在非感染性呼吸衰竭患者中也产生了令人振奋的结果。本文综述了多粘菌素B固定化小柱的免疫调节作用，以探索其在清除内毒素之外的潜在用途。
Severe sepsis results in high morbidity and mortality. Immunomodulation strategies could be an adjunctive therapy to treat sepsis. Endotoxin is a component of gram-negative bacteria and plays an important role in the pathogenesis of septic shock when it is recognized by immune cells. Removal of endotoxin could be an effective adjunctive approach to the management of sepsis. Devices to adsorb endotoxin or inflammatory cytokines have been designed as a strategy to treat severe sepsis, especially sepsis caused by gram-negative bacteria. Polymyxin B-immobilized cartridge has been successfully used to treat patients with sepsis of abdominal origin. Although this cartridge was conceived to adsorb endotoxin, several other immunological mechanisms have been elucidated, and this device has also yielded promising results in patients with nonseptic respiratory failure. In this paper, we summarize the immune modulation actions of Polymyxin B-immobilized cartridge to explore its potential usefulness beyond endotoxin elimination.
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影响因子：
120.7
作者：
Boomer, Jonathan S.;To, Kathleen;Chang, Kathy C.;Takasu, Osamu;Osborne, Dale F.;Walton, Andrew H.;Bricker, Traci L.;Jarman, Stephen D., II;Kreisel, Daniel;Krupnick, Alexander S.;Srivastava, Anil;Swanson, Paul E.;Green, Jonathan M.;Hotchkiss, Richard S.
通讯作者：
Hotchkiss, Richard S.
影响因子：
1.2
作者：
Abe, Shinji;Azuma, Arata;Sugiyama, Yukihiko
通讯作者：
Sugiyama, Yukihiko
影响因子：
3.7
作者：
Hara, Shintaro;Ishimoto, Hiroshi;Kohno, Shigeru
通讯作者：
Kohno, Shigeru
影响因子：
120.7
作者：
Ferrer, Ricard;Artigas, Antonio;de la Torre-Prados, Maria Victoria
通讯作者：
de la Torre-Prados, Maria Victoria
影响因子：
38.9
作者：
Gibot, Sebastien;Massin, Frederic;Bollaert, Pierre-Edouard
通讯作者：
Bollaert, Pierre-Edouard