In vivo antiplasmodial and toxicological effect of Maytenus senegalensis traditionally used in the treatment of malaria in Tanzania.
In vivo antiplasmodial and toxicological effect of Maytenus senegalensis traditionally used in the treatment of malaria in Tanzania.
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DOI：
10.1186/s12936-014-0525-y
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发表时间：
2015-02-14
期刊：
影响因子：
3
通讯作者：
Kitua AY
中科院分区：
文献类型：
--
作者：
Malebo HM;Wiketye V;Katani SJ;Kitufe NA;Nyigo VA;Imeda CP;Ogondiek JW;Sunguruma R;Mhame PP;Massaga JJ;Mammuya B;Senkoro KP;Rumisha SF;Malecela MN;Kitua AY
在坦桑尼亚和其他地方，包括塞内加尔美登木在内的药用植物仍被广泛用于治疗疟疾和其他疾病。本研究的目的是研究在小鼠体内抗疟原虫和毒性作用。采用口服抗疟原虫和急性毒性试验研究了甘草乙醇提取物的抗疟原虫作用。在小鼠中评价了塞内加尔人链球菌。Peters对氯喹敏感的伯氏疟原虫NK 65株小鼠早期感染的4天体内抗疟原虫作用分枝发现塞内加尔提取物无毒，经测定，小鼠口服半数致死剂量大于1，600毫克/千克体重。结果显示，在寄生虫未处理组中，寄生虫血症水平每日显著增加（P = 0.001），在用25 - 100 mg/kg体重范围内的不同剂量M处理的寄生虫组中，寄生虫血症水平呈剂量依赖性显著降低（P < 0.001）。塞内加尔提取物和25/1.25 mg/kg体重的标准药物磺胺嘧啶/乙胺嘧啶。总的来说，剂量依赖性的寄生虫血症抑制效果的顺序为：25/1.25 mg/kg体重的磺胺嘧啶/乙胺嘧啶> 100 mg/kg > 75 mg/kg > 50 mg/kg > 25 mg/kg体重的M。塞内加尔提取物这些发现的含义是，M。塞内加尔根皮乙醇提取物具有有效的抗疟原虫作用，因此可作为安全、有效和负担得起的抗疟疾药物的潜在来源。在体内表现出的高抗疟原虫活性和缺乏毒性作用使M. senegalensis是生物测定指导的化合物分离的候选者，这些化合物可以发展成新的先导结构，也是防治人类疟疾药物开发方案的候选者。
In Tanzania and elsewhere, medicinal plants, including Maytenus senegalensis, are still widely used in the treatment of malaria and other ailments. The aim of the present study was to investigate the in vivo antiplasmodial and toxic effects in mice. Oral antiplasmodial and acute toxicity of the ethanolic root extract of M. senegalensis was evaluated in mice. The Peters 4-day in vivo antiplasmodial effect against early rodent malaria infection in chloroquine-sensitive Plasmodium berghei NK 65 strain in mice. The M. senegalensis extract was found non-toxic and the oral median lethal dose in mice was determined to be greater than 1,600 mg/kg body weight. The findings revealed a significant (P = 0.001) daily increase in the level of parasitaemia in the parasitized untreated groups and a significant (P < 0.001) dose dependent decrease in parasitaemia in the parasitized groups treated with varying doses ranging from 25 to 100 mg/kg body weight of M. senegalensis extract and the standard drug sulphadoxine/pyrimethamine at 25/1.25 mg/kg body weight. Overall, the dose dependent parasitaemia suppression effects were in the order of: 25/1.25 mg/kg body weight of sulphadoxine/pyrimethamine > 100 mg/kg > 75 mg/kg > 50 mg/kg > 25 mg/kg body weight of M. senegalensis extract. The implications of these findings is that M. senegalensis ethanolic root bark extract possess potent antiplasmodial effect and may, therefore, serve as potential sources of safe, effective and affordable anti-malarial drugs. The displayed high in vivo antiplasmodial activity and lack of toxic effect render M. senegalensis a candidate for the bioassay-guided isolation of compounds which could develop into new lead structures and candidates for drug development programmes against human malaria.
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影响因子：
2.8
作者：
da Silva, G.;Tanica, M.;Silva, O.
通讯作者：
Silva, O.
DOI：
10.1111/j.1467-8276.2009.01252.x
发表时间：
2009-05-01
影响因子：
4.2
作者：
Klemick, Heather;Leonard, Kenneth L.;Masatu, Melkiory C.
通讯作者：
Masatu, Melkiory C.
影响因子：
--
作者：
Peters, W;Fleck, SL;Jefford, CW
通讯作者：
Jefford, CW
影响因子：
--
作者：
Ahmed AS;McGaw LJ;Eloff JN
通讯作者：
Eloff JN
影响因子：
2.7
作者：
GESSLER, MC;NKUNYA, MHH;TANNER, M
通讯作者：
TANNER, M