Endometrial thickness affects the outcome of in vitro fertilization and embryo transfer in normal responders after GnRH antagonist administration.
Endometrial thickness affects the outcome of in vitro fertilization and embryo transfer in normal responders after GnRH antagonist administration.
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DOI：
10.1186/1477-7827-12-96
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发表时间：
2014-10-09
期刊：
影响因子：
--
通讯作者：
Xi X
中科院分区：
文献类型：
--
作者：
Wu Y;Gao X;Lu X;Xi J;Jiang S;Sun Y;Xi X
本研究的目的是评估绒毛膜促性腺激素（hCG）日子宫内膜厚度与GnRH拮抗剂给药后正常应答者体外受精-胚胎移植（IVF-ET）结局之间的相关性。在2011年1月至2013年12月接受GnRH拮抗剂给药的正常应答者中进行了一项回顾性队列研究。根据子宫内膜厚度将患者分为以下四组：<7 mm（组1），> = 7- < 8 mm（组2），> = 8- < 14 mm（组3）和> =14 mm（组4）。共分析了2106个胚胎移植周期。妊娠率为44.87%。第1组的临床妊娠率、继续妊娠率和种植率（分别为17.28%、13.79%、10.17%）均显著低于其他3组（P < 0.05）。子宫内膜厚度小于7 mm的患者流产率较高。子宫内膜厚度> 14 mm患者的临床妊娠率、继续妊娠率和种植率最高，而子宫内膜厚度在8-14 mm患者的临床妊娠率、继续妊娠率和种植率无显著差异。hCG日测量的子宫内膜厚度与GnRH拮抗剂给药的正常应答者的临床结局之间存在相关性。子宫内膜厚度小于7 mm的患者妊娠率低于子宫内膜厚度大于7 mm的患者。
The goal of this study was to assess the association between endometrial thickness on the chorionic gonadotropin (hCG) day and in vitro fertilization and embryo transfer (IVF-ET) outcome in normal responders after GnRH antagonist administration. A retrospective cohort study was performed in normal responders with GnRH antagonist administration from January 2011–December 2013. Patients were divided into four groups according to endometrial thickness, as follows: <7 mm (group 1), > = 7- < 8 mm (group 2), > = 8- < 14 mm (group 3), and > =14 mm (group 4). A total of 2106 embryo transfer cycles were analyzed. The pregnancy rate (PR) was 44.87%. The clinical pregnancy rate, ongoing pregnancy rate and the implantation rate (17.28%, 13.79%, 10.17%, respectively) were significantly lower in group 1 compared to the other three groups (p < 0.05). The miscarriage rate was higher in patients with endometrial thickness less than 7 mm. The clinical pregnancy rate, ongoing pregnancy rate and implantation rate were highest in patients with endometrial thickness higher than 14 mm, but showed no difference in patients with those of endometrial thickness between 8-14 mm. There is a correlation between endometrial thickness measured on hCG day and clinical outcome in normal responders with GnRH antagonist administration. The pregnancy rate was lower in patients with endometrial thickness less than 7 mm compared with patients with endometrial thickness more than 7 mm.
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DOI：
10.1111/j.1600-0897.2009.00792.x
发表时间：
2010-01
期刊：
American journal of reproductive immunology (New York, N.Y. : 1989)
影响因子：
--
作者：
Dekel N;Gnainsky Y;Granot I;Mor G
通讯作者：
Mor G
影响因子：
3.1
作者：
Detti, Laura;Ambler, Dana R.;Puscheck, Elizabeth E.
通讯作者：
Puscheck, Elizabeth E.
影响因子：
2
作者：
Qiao, Jie;Lu, Guangxiu;Mannaerts, Bernadette
通讯作者：
Mannaerts, Bernadette
影响因子：
6.1
作者：
Ferraretti, A. P.;La Marca, A.;Gianaroli, L.
通讯作者：
Gianaroli, L.
影响因子：
2.3
作者：
Detti, Laura;Yelian, Frank D.;Puscheck, Elizabeth E.
通讯作者：
Puscheck, Elizabeth E.