Impaired inhibitory processing: a new therapeutic target for autism and psychosis?

Impaired inhibitory processing: a new therapeutic target for autism and psychosis?
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抑制加工受损:自闭症和精神病的新治疗靶点?

DOI:
10.1192/bjp.2020.163
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发表时间:
2021-06
期刊:
The British journal of psychiatry : the journal of mental science
影响因子:
--
通讯作者:
Broome MR
Broome MR
中科院分区:
其他
文献类型:
--
作者:
Heinze K;Barron HC;Howes EK;Ramaswami M;Broome MR

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在健康的大脑中,兴奋和抑制之间的稳态平衡维持神经稳定性。然而,这种平衡的紊乱可以解释自闭症和精神病中观察到的共同症状。在这里,我们回顾了证据,表明γ-氨基丁酸(GABA)水平的改变可能是这两种疾病的基础,提供了潜在的交叉诊断治疗靶点。
In the healthy brain, homeostatic balance between excitation and inhibition maintains neural stability. However, disturbances to this balance may explain shared symptoms observed in autism and psychosis. Here we review evidence suggesting that altered levels of gamma-amino butyric acid (GABA) may underlie both disorders, providing a potential cross-diagnostic therapeutic target.
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