Feasibility of event-related potential (ERP) biomarker use to study effects of mother's voice exposure on speech sound differentiation of preterm infants.

Feasibility of event-related potential (ERP) biomarker use to study effects of mother's voice exposure on speech sound differentiation of preterm infants.
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DOI:
10.1080/87565641.2018.1433671
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发表时间:
2018
影响因子:
1.5
通讯作者:
Maitre NL
Maitre NL
中科院分区:
心理学4区
文献类型:
--
作者:
D Chorna O;L Hamm E;Shrivastava H;Maitre NL

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听觉神经加工的非典型成熟与早产儿语言发育迟缓有关。事件相关电位(ERP)测量语音分化可能填补听觉干预治疗反应生物标志物的空白。我们在一项准随机前瞻性研究中评估了这些标记物是否可以衡量治疗效果。住院早产儿在被动或主动,吸吮偶然母亲的声音暴露组在基线上没有差异。干预后,活跃组左侧额叶和颞叶区域的/du/-/gu/分化增加更大。脑损伤婴儿的/ba/-/ga/和/du/-/gu/分化基线低于无脑损伤婴儿。ERP为婴儿语音分化提供了有效的判别性、反应性和预测性的生物标志物。
Atypical maturation of auditory neural processing contributes to preterm-born infants’ language delays. Event-Related Potential (ERP) measurement of speech-sound differentiation might fill a gap in treatment-response biomarkers to auditory interventions. We evaluated whether these markers could measure treatment effects in a quasi-randomized prospective study. Hospitalized preterm infants in passive or active, suck-contingent mother’s voice exposure groups were not different at baseline. Post-intervention, the active group had greater increases in /du/-/gu/differentiation in left frontal and temporal regions. Infants with brain injury had lower baseline /ba/-/ga/and /du/-/gu/ differentiation than those without. ERP provides valid discriminative, responsive, and predictive biomarkers of infant speech-sound differentiation.
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