The Future of Cell Biology: Emerging Model Organisms.

The Future of Cell Biology: Emerging Model Organisms.
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DOI:
10.1016/j.tcb.2016.08.005
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发表时间:
2016-11
影响因子:
19
通讯作者:
King, Nicole
King, Nicole
中科院分区:
生物学1区
文献类型:
--
作者:
Goldstein, Bob;King, Nicole

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目前细胞生物学的大多数研究仅使用少数模型系统,包括酵母、拟南芥、果蝇、线虫、斑马鱼、小鼠和培养的哺乳动物细胞。出于充分的理由,对于许多生物学问题,可能会在这些模型中找到解决该问题的最佳系统。但在某些情况下,特别是随着科学家关注的问题不断扩大,解决某个问题的最佳系统可能是一个很少被研究的有机体。现代研究工具正在促进不寻常且有趣的生物体作为新兴模型系统的复兴。因此,我们预测模型系统的不断扩大可能是未来细胞生物学的一个标志。
Most current research in cell biology uses just a handful of model systems including yeast, Arabidopsis, Drosophila, C. elegans, zebrafish, mouse, and cultured mammalian cells. And for good reason—for many biological questions, the best system for the question is likely to be found among these models. But in some cases, and particularly as the questions that engage scientists broaden, the best system for a question may be a little-studied organism. Modern research tools are facilitating a renaissance for unusual and interesting organisms as emerging model systems. As a result, we predict that an ever-expanding breadth of model systems may be a hallmark of future cell biology.
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