Translational/personalized medicine, pharmaco/surgico/radiogenomics, lymphatic spread of cancer, and medical ignoromes.

Translational/personalized medicine, pharmaco/surgico/radiogenomics, lymphatic spread of cancer, and medical ignoromes.
复制标题

DOI:
10.1002/jso.21738
复制
发表时间:
2011-05-01
影响因子:
2.5
通讯作者:
Witte, Marlys H.
Witte, Marlys H.
中科院分区:
医学3区
文献类型:
--
作者:
Witte, Marlys H.

文献摘要

参考文献

被引文献

相似文献

在基于药物基因组学的“个性化”癌症治疗的难以捉摸的探索中,必须克服各种挑战:“生命分子模型”的有效性值得怀疑,科学进步从实验室到临床到社区双向转化的障碍,以及生物信息学在识别和处理“无知/无知组”(癌症生物学、治疗诊断学和治疗选择中不断扩大的未知数)方面的局限性。这些考虑因素适用于癌症等疾病中的淋巴系统功能(淋巴管、淋巴液、淋巴结和淋巴细胞)。
In the elusive quest for “personalized” cancer treatments based on pharmacogenomics, diverse challenges must be overcome: questionable validity of “molecular models of life,” obstacles to bidirectional translation of scientific advances from bench to bedside to community, and limitations of bioinformatics to recognize and deal with “ignoramics/ignoromes” (expanding unknowns in cancer biology, theranostics, and therapeutic choices). These considerations apply to lymphatic system functioning—lymphatic vessels, lymph, lymph nodes, and lymphocytes—in diseases like cancer.
DOI: 10.1016/s1534-5807(02)00217-4
发表时间: 2002-09-01
期刊: DEVELOPMENTAL CELL
影响因子: 11.8
作者:
Gale, NW;Thurston, G;Yancopoulos, GD
通讯作者: Yancopoulos, GD
研究肺炎球菌类型的诱导物质转化的化学性质:通过从III型肺炎球菌分离出的脱氧核糖核酸分数诱导转化。
DOI: 10.1084/jem.79.2.137
发表时间: 1944-02-01
期刊: The Journal of experimental medicine
影响因子: --
作者:
Avery OT;Macleod CM;McCarty M
通讯作者: McCarty M
DOI: 10.1093/hmg/ddg123
发表时间: 2003-05-15
影响因子: 3.5
作者:
Kriederman, BM;Myloyde, TL;Glover, TW
通讯作者: Glover, TW
DOI: 10.1002/aja.1000010310
发表时间: 1902-05-01
影响因子: --
作者:
Sabin, FR
通讯作者: Sabin, FR
DOI: 10.1086/316915
发表时间: 2000-12-01
影响因子: 9.8
作者:
Fang, JM;Dagenais, SL;Glover, TW
通讯作者: Glover, TW