Viscoelastic properties of human aryepiglottic fold and ventricular fold tissues at phonatory frequencies.
Viscoelastic properties of human aryepiglottic fold and ventricular fold tissues at phonatory frequencies.
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DOI：
10.1002/lary.27049
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发表时间：
2018-08
期刊：
影响因子：
--
通讯作者：
Chan RW
中科院分区：
文献类型：
--
作者：
Kimura M;Chan RW
本研究的目的是定量测定发声频率下人的室折(或假声带)粘膜和会厌折黏膜的粘弹性剪切特性。本文测定了7具身体标本假声带和会厌褶黏膜的线性粘弹性剪切特性随频率的变化(5-250赫兹)，并与真声带盖的粘弹性特性进行了比较。用控制应变单剪切流变仪测定了聚合物的弹性剪切模数(G‘)和动态粘度(η’)。用线性最小二乘回归拟合对数G‘和对数η’与对数频率的关系，并用单因素方差分析进行统计分析。所有试件的粘弹性函数G‘和η’均表现出相似的频率依赖性，G‘随频率逐渐增大，η’随频率单调减小。假折黏膜的G‘和η’值普遍高于会厌折黏膜和真声带盖，但会厌折和会厌折与真声带之间的G‘和η’值无显著差异。假声带和会厌褶黏膜表现出与真声带相似的频率依赖性和相似的组织粘弹性行为范围。这些初步发现表明，对于有明显组织丢失和缺失的患者，对于那些需要部分喉切除或气道重建后需要喉重建的患者，这些组织可能成为替代真正声带固有层的候选组织。
The purpose of this study was to quantify the viscoelastic shear properties of the human ventricular fold (or false vocal fold) mucosa and aryepiglottic fold mucosa at frequencies of phonation. Linear viscoelastic shear properties of the mucosa of false vocal fold and aryepiglottic fold specimens from 7 cadaveric subjects were determined as functions of frequency (5–250Hz), and compared to those of the true vocal fold cover. Measurements of elastic shear modulus (G′) and dynamic viscosity (η′) were made with a controlled-strain simple-shear rheometer. Linear least-squares regression was conducted to curve-fit log G′ and log η′ versus log frequency, and statistical analysis was performed with one-way ANOVA. All specimens showed similar frequency dependence of the viscoelastic functions G′ and η′, with G′ gradually increasing with frequency and η′ monotonically decreasing with frequency. The magnitudes of G′ and η′ of the false fold mucosa were generally higher than those of the aryepiglottic fold mucosa and true vocal fold cover, but there were no significant differences in G′ and η′ among the false fold, aryepiglottic fold and true vocal fold. The false vocal fold and aryepiglottic fold mucosa showed similar frequency dependence and a similar range of tissue viscoelastic behavior as the true vocal fold. These preliminary findings suggested that such tissues could become candidates for the replacement of the true vocal fold lamina propria in patients with significant tissue loss and deficiencies, for those requiring laryngeal reconstruction following partial laryngectomy or airway reconstruction.
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