Non-invasive in vivo measurement of the shear modulus of human vocal fold tissue.
Non-invasive in vivo measurement of the shear modulus of human vocal fold tissue.
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DOI：
10.1016/j.jbiomech.2013.11.034
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发表时间：
2014-03-21
影响因子：
2.4
通讯作者：
Kost, Karen
中科院分区：
文献类型：
--
作者：
Kazemirad, Siavash;Bakhshaee, Hani;Mongeau, Luc;Kost, Karen
声音是歌唱和言语交际中不可缺少的部分。语音障碍严重影响生活质量。声带粘膜的粘弹性力学性质决定了声带振动的特性，从而决定了嗓音的质量。在本研究中，开发了一种非侵入性的方法来确定在体内的人类声带组织的剪切模量通过测量的粘膜波传播速度在发声。使用高速数字成像（HSDPA）和磁共振成像（MRI）针对不同的发声音高（特别是110至440 Hz之间的基频）捕获四个人类受试者的声带的图像。MRI图像用于获得每个受试者的声带的形态测量尺寸，以确定高速图像中的像素大小。使用自动图像处理算法确定每个受试者和每个音调值的粘膜波传播速度。声带粘膜的横向剪切模量，然后从表面（瑞利）波传播色散方程使用测得的波速计算。结果发现，粘膜波的传播速度，因此声带组织的剪切模量一般较大，在较高的音高。结果是在良好的协议，从其他研究中获得通过在体外测量，从而支持所提出的测量方法的有效性。这种方法提供了潜在的在体内临床评估声带粘弹性从HSDI。
Voice is the essential part of singing and speech communication. Voice disorders significantly affect the quality of life. The viscoelastic mechanical properties of the vocal fold mucosa determine the characteristics of the vocal folds oscillations, and thereby voice quality. In the present study, a non-invasive method was developed to determine the shear modulus of human vocal fold tissue in vivo via measurements of the mucosal wave propagation speed during phonation. Images of four human subjects’ vocal folds were captured using high speed digital imaging (HSDI) and magnetic resonance imaging (MRI) for different phonation pitches, specifically fundamental frequencies between 110 to 440 Hz. The MRI images were used to obtain the morphometric dimensions of each subject's vocal folds in order to determine the pixel size in the high-speed images. The mucosal wave propagation speed was determined for each subject and at each pitch value using an automated image processing algorithm. The transverse shear modulus of the vocal fold mucosa was then calculated from a surface (Rayleigh) wave propagation dispersion equation using the measured wave speeds. It was found that the mucosal wave propagation speed and therefore the shear modulus of the vocal fold tissue were generally greater at higher pitches. The results were in good agreement with those from other studies obtained via in vitro measurements, thereby supporting the validity of the proposed measurement method. This method offers the potential for in vivo clinical assessments of vocal folds viscoelasticity from HSDI.
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