Design of DNA origami

Design of DNA origami
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DNA折纸设计

DOI:
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发表时间:
2005
期刊:
ICCAD. IEEE/ACM International Conference on Computer-Aided Design
影响因子:
--
通讯作者:
P. Rothemund
P. Rothemund
中科院分区:
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文献类型:
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作者:
P. Rothemund

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在非常小的尺度上产生任意图案和形状是我们努力实现电路集成的核心,也是纳米技术发展的基础。在这里,我回顾了最近开发的一种方法,折叠成任意的二维形状的长单链DNA使用光栅填充技术-“脚手架DNA折纸”。直径高达100纳米的纳米线可以近似为6纳米的分辨率,并在相同的分辨率下装饰有大约200个二进制像素的图案。实验验证了十几个形状和图案的创建,该方法是简单的,高产量,以及适合于自动化设计和制造。到目前为止,用于支架DNA折纸的CAD工具很简单,需要手工设计折叠路径,并且仅限于二维设计。如果该方法获得广泛接受,将需要更好的CAD工具。
The generation of arbitrary patterns and shapes at very small scales is at the heart of our effort to miniaturize circuits and is fundamental to the development of nanotechnology. Here I review a recently developed method for folding long single strands of DNA into arbitrary two-dimensional shapes using a raster fill technique - 'scaffolded DNA origami'. Shapes up to 100 nanometers in diameter can be approximated with a resolution of 6 nanometers and decorated with patterns of roughly 200 binary pixels at the same resolution. Experimentally verified by the creation of a dozen shapes and patterns, the method is easy, high yield, and lends itself well to automated design and manufacture. So far, CAD tools for scaffolded DNA origami are simple, require hand-design of the folding path, and are restricted to two dimensional designs. If the method gains wide acceptance, better CAD tools will be required.
DOI: 10.1021/bi00064a003
发表时间: 1993-04-06
期刊: BIOCHEMISTRY
影响因子: 2.9
作者:
FU, TJ;SEEMAN, NC
通讯作者: SEEMAN, NC
DOI: 10.1080/07391102.1990.10507829
发表时间: 1990-12-01
影响因子: 4.4
作者:
SEEMAN, NC
通讯作者: SEEMAN, NC
DOI: 10.1016/0022-5193(82)90002-9
发表时间: 1982-01-01
影响因子: 2
作者:
SEEMAN, NC
通讯作者: SEEMAN, NC