Crème de la Créature: Dietary Influences on Behavior in Animal Models.

Crème de la Créature: Dietary Influences on Behavior in Animal Models.
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DOI:
10.3389/fnbeh.2021.746299
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发表时间:
2021
影响因子:
3
通讯作者:
Dus M
Dus M
中科院分区:
医学3区
文献类型:
--
作者:
Sarangi M;Dus M

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在人类中,认知、动机和情感行为的变化被描述为摄入高精制糖和饱和脂肪的加工饮食以及高体重指数,但这些变化的原因、机制和后果仍然知之甚少。动物模型提供了一个回答这些问题的机会,并阐明了饮食结构,特别是高水平的添加糖和饱和脂肪,对大脑生理、可塑性和行为的贡献。在这里,我们回顾了无脊椎动物(苍蝇)和脊椎动物模型(啮齿动物、斑马鱼)的研究结果,这些发现表明这些饮食与包括进食、学习和记忆以及动机在内的多种行为的变化有关,并讨论了局限性、开放问题和未来的机会。
In humans, alterations in cognitive, motivated, and affective behaviors have been described with consumption of processed diets high in refined sugars and saturated fats and with high body mass index, but the causes, mechanisms, and consequences of these changes remain poorly understood. Animal models have provided an opportunity to answer these questions and illuminate the ways in which diet composition, especially high-levels of added sugar and saturated fats, contribute to brain physiology, plasticity, and behavior. Here we review findings from invertebrate (flies) and vertebrate models (rodents, zebrafish) that implicate these diets with changes in multiple behaviors, including eating, learning and memory, and motivation, and discuss limitations, open questions, and future opportunities.
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