Pharmacoendocrinology of major depression
Pharmacoendocrinology of major depression
复制标题
重度抑郁症的药物内分泌学
DOI：
10.1007/bf00449807
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
R. Rubin
中科院分区：
文献类型：
--
作者：
R. Rubin
主要抑郁症患者的脑垂体前叶激素和靶向内分泌腺激素的分泌模式经常出现异常。基础荷尔蒙分泌和这些荷尔蒙对扰动试验的反应都有变化。已经做了大量的工作，试图开发这些变化中的一些作为内源性抑郁的生物状态标志的临床应用。其中突出的变化是下丘脑-垂体-肾上腺皮质(HPA)轴过度活跃。地塞米松抑制试验(DST)作为HPA轴活动的一种反映，是迄今为止精神病学研究最深入的“生物学试验”。相当少的研究涉及抑郁症中HPA轴调节的更基本的问题，例如DST前皮质醇过度分泌和DST结果之间的关系。第二个被广泛研究的抑郁症内分泌轴是下丘脑-垂体-甲状腺(HPT)轴。大多数研究都涉及促甲状腺激素对外源性促甲状腺激素释放激素的反应。虽然与正常对照组相比，抑郁症患者的TSH反应迟钝，但在其他类型的精神疾病患者中，反应迟钝的频率使这项测试对鉴别诊断略有帮助。已报道的其他激素轴的变化，例如，抑郁症患者对几个挑战的生长激素反应迟钝，目前还没有足够彻底的调查来支持它们的普遍临床应用。由于相同的中枢神经系统(CNS)神经递质似乎既参与了情感的调节，也参与了下丘脑释放和抑制因子的调节，因此很容易认为抑郁状态和上述内分泌动力学改变都与常见的CNS神经递质功能障碍有关。然而，提出这一假设要比证明它容易得多。
SummaryMajor depressives often have abnormalities in the secretion patterns of their anterior pituitary hormones and target endocrine gland hormones. There are changes in both basal hormone secretion and the responses of these hormones to perturbation tests. Considerable work has been done attempting to develop a clinical application for some of these changes as biological state markers of endogenous depression. Prominent among the changes is an overactivity of the hypothalamo-pituitary-adrenocortical (HPA) axis. The dexamethasone suppression test (DST), as a reflection of HPA axis activity, has been the most thoroughly investigated “biological test” in psychiatry to date. Considerably fewer studies have addressed more fundamental issues of HPA axis regulation in depression, such as the relationship between pre-DST cortisol hypersecretion and DST outcome. The next most widely investigated endocrine axis in depression has been the hypothalamo-pituitary-thyroid (HPT) axis. Most studies have dealt with the TSH response to exogenously administered thyrotropin releasing hormone. While blunted TSH responses have been found in depressives compared with normal controls, the frequency of blunted responses in other types of psychiatric patients has made this test marginally useful for differential diagnosis. The reported changes in other hormone axes, for example the blunted growth hormone response to several challenges noted in depressed patients, have not been investigated sufficiently thoroughly to support their general clinical use at present. Because the same putative central nervous system (CNS) neurotransmitters appear to be involved in both the modulation of affects and the regulation of the hypothalamic releasing and inhibiting factors, it is tempting to suggest that a common CNS neurotransmitter dysfunction underlies both the depressive state and the aforementioned altered endocrine dynamics. However, proposing this hypothesis has been considerably easier than demonstrating it.
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地塞米松对精神病患者血浆催乳素和皮质醇水平的影响。
DOI：
10.1176/ajp.139.6.763
发表时间：
1982
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Meltzer,HY;Fang,VS;Tricou,BJ;Robertson,A;Piyaka,SK
通讯作者：
Piyaka,SK
影响因子：
--
作者：
B. Carroll;M. Feinberg;J. Greden;J. Tarika;A. Albala;R. Haskett;Norman McI. James;Z. Kronfol;N. Lohr;M. Steiner;Jean Paul de Vigne;E. Young
通讯作者：
B. Carroll;M. Feinberg;J. Greden;J. Tarika;A. Albala;R. Haskett;Norman McI. James;Z. Kronfol;N. Lohr;M. Steiner;Jean Paul de Vigne;E. Young
重度抑郁症的下丘脑-垂体-肾上腺轴活动和三环反应。
影响因子：
--
作者：
Nelson,WH;OrrJr,WW;Stevenson,JM;Shane,SR
通讯作者：
Shane,SR
使用 TSH 对 TRH 的反应作为自变量。
DOI：
10.1176/ajp.140.6.700
发表时间：
1983
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Loosen,PT;Kistler,K;PrangeJr,AJ
通讯作者：
PrangeJr,AJ
影响因子：
--
作者：
Poland,RE;Rubin,RT;Lesser,IM;Lane,LA;Hart,PJ
通讯作者：
Hart,PJ