Iron-responsive bacterial small RNAs: variations on a theme.
Iron-responsive bacterial small RNAs: variations on a theme.
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DOI：
10.1039/c3mt20224k
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发表时间：
2013-04
期刊：
影响因子：
--
通讯作者：
Murphy ER
中科院分区：
文献类型：
--
作者：
Oglesby-Sherrouse AG;Murphy ER
对于大多数生物体来说，铁既是必需的，又具有潜在的毒性，因此精确维持铁稳态是生存所必需的。为了解决这一悖论，细菌根据铁的可用性来调节铁的获取、利用和储存。铁依赖性铁摄取阻遏蛋白（Fur）通常通过直接和间接机制介导这种铁反应性调节。 2002 年，Masse 和 Gottesman 在大肠杆菌中发现了 Fur 介导的调节的新靶标：编码称为 RyhB 的小调节 RNA (sRNA) 的基因。在铁限制条件下，RyhB 产生并发挥作用，调节编码铁利用酶、铁获取系统和铁储存因子的多个靶基因的表达。这一关键发现提供了环境铁限制与之前观察到的某些铁依赖性代谢途径减少之间缺失的联系，这种现象现在被称为“铁节约”反应。 RyhB 的发现为快速扩展的细菌铁调节 sRNA 领域打开了大门，这些 sRNA 继续在许多细菌物种中被识别和描述。最引人注目的发现是，铁响应性 sRNA 调节的影响往往超出铁稳态，特别是在病原菌产生毒力相关因子方面。这篇综述讨论了铁调节 sRNA 的集体工作趋势，强调了它们用来控制靶基因表达的调节机制，以及这种调节对控制细菌生理学和毒力的基本过程的影响。
For most living organisms, iron is both essential and potentially toxic, making the precise maintenance of iron homeostasis necessary for survival. To manage this paradox, bacteria regulate the acquisition, utilization, and storage of iron in response to its availability. The iron-dependent ferric uptake repressor (Fur) often mediates this iron-responsive regulation, by both direct and indirect mechanisms. In 2002, Masse and Gottesman identified a novel target of Fur-mediated regulation in Escherichia coli: a gene encoding a small regulatory RNA (sRNA) termed RyhB. Under conditions of iron-limitation, RyhB is produced and functions to regulate the expression of several target genes encoding iron-utilizing enzymes, iron acquisition systems, and iron storage factors. This pivotal finding provided the missing link between environmental iron-limitation and previously observed decreases in certain iron-dependent metabolic pathways, a phenomenon now referred to as an “iron-sparing” response. The discovery of RyhB opened the door to the rapidly expanding field of bacterial iron-regulated sRNAs, which continue to be identified and described in numerous bacterial species. Most striking are findings that the impact of iron-responsive sRNA regulation often extends beyond iron homeostasis, particularly with regard to production of virulence-associated factors by pathogenic bacteria. This review discusses trends in the collective body of work on iron-regulated sRNAs, highlighting both the regulatory mechanisms they utilize to control target gene expression and the impact of this regulation on basic processes controlling bacterial physiology and virulence.
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影响因子：
14.9
作者：
Afonyushkin, T;Vecerek, B;Moll, I;Bläsi, U;Kaberdin, VR
通讯作者：
Kaberdin, VR
DOI：
10.1073/pnas.0600927103
发表时间：
2006-05-02
影响因子：
11.1
作者：
Dühring, U;Axmann, IM;Wilde, A
通讯作者：
Wilde, A
影响因子：
6.7
作者：
Friedman DB;Stauff DL;Pishchany G;Whitwell CW;Torres VJ;Skaar EP
通讯作者：
Skaar EP
影响因子：
--
作者：
Diggle, Stephen P.;Matthijs, Sandra;Williams, Paul
通讯作者：
Williams, Paul
影响因子：
3.2
作者：
ACTIS, LA;FISH, W;SANDERSLOEHR, J
通讯作者：
SANDERSLOEHR, J