D-Tagatose Feeding Reduces the Risk of Sugar-Induced Exacerbation of Myocardial I/R Injury When Compared to Its Isomer Fructose.
D-Tagatose Feeding Reduces the Risk of Sugar-Induced Exacerbation of Myocardial I/R Injury When Compared to Its Isomer Fructose.
复制标题
DOI：
10.3389/fmolb.2021.650962
复制
发表时间：
2021
影响因子：
5
通讯作者：
Collino M
中科院分区：
文献类型：
--
作者：
Durante M;Sgambellone S;Lucarini L;Failli P;Laurino A;Collotta D;Provensi G;Masini E;Collino M
已知果糖可能导致心肌对缺血/再灌注（I/R）损伤的脆弱性。D-塔格糖是一种果糖异构体，具有较低的热量值，用作低热量甜味剂。在这里，我们比较了富含果糖或D-塔格糖的饮食对心肌I/R损伤潜在加重的代谢影响。将Wistar大鼠随机分配到实验组中，并喂食以下饮食之一：对照（CTRL）、富含30%果糖（FRU 30%）或富含30%D-塔格糖（TAG 30%）。饮食干预24周后，结扎大鼠冠状动脉左前降支（LAD）30 min，再灌注24 h，造成心肌损伤。果糖摄入导致体重增加（49%）以及葡萄糖、胰岛素和脂质谱改变。这些作用与I/R诱导的心肌损伤、氧化应激（36.5%）和炎症标志物表达增加有关。TAG 30%喂养的大鼠显示出较低的氧化应激（21%）和炎症相比，水果喂养的大鼠。此外，TAG饮食显著降低血浆炎性细胞因子和GDF 8表达（50%），同时增加心肌内皮型一氧化氮合酶（eNOS）表达（59%）。总体而言，我们证明，D-塔格糖是一个有趣的糖替代品相比，其异构体果糖减少有害影响，不仅对代谢谱，而且对相关的心脏易感性I/R损伤。
It is known that fructose may contribute to myocardial vulnerability to ischemia/reperfusion (I/R) injury. D-tagatose is a fructose isomer with less caloric value and used as low-calorie sweetener. Here we compared the metabolic impact of fructose or D-tagatose enriched diets on potential exacerbation of myocardial I/R injury. Wistar rats were randomizedly allocated in the experimental groups and fed with one of the following diets: control (CTRL), 30% fructose-enriched (FRU 30%) or 30% D-tagatose-enriched (TAG 30%). After 24 weeks of dietary manipulation, rats underwent myocardial injury caused by 30 min ligature of the left anterior descending (LAD) coronary artery followed by 24 h′ reperfusion. Fructose consumption resulted in body weight increase (49%) as well as altered glucose, insulin and lipid profiles. These effects were associated with increased I/R-induced myocardial damage, oxidative stress (36.5%) and inflammation marker expression. TAG 30%-fed rats showed lower oxidative stress (21%) and inflammation in comparison with FRU-fed rats. Besides, TAG diet significantly reduced plasmatic inflammatory cytokines and GDF8 expression (50%), while increased myocardial endothelial nitric oxide synthase (eNOS) expression (59%). Overall, we demonstrated that D-tagatose represents an interesting sugar alternative when compared to its isomer fructose with reduced deleterious impact not only on the metabolic profile but also on the related heart susceptibility to I/R injury.
登录
查看更多内容
影响因子：
5.7
作者：
Abbate, A;Santini, D;Baldi, A
通讯作者：
Baldi, A
影响因子：
5.6
作者：
Mastrocola, Raffaella;Ferrocino, Ilario;Collino, Massimo
通讯作者：
Collino, Massimo
影响因子：
2.9
作者：
Hu, Frank B.;Malik, Vasanti S.
通讯作者：
Malik, Vasanti S.
影响因子：
5.6
作者：
Liang, Yu-Xuan;Wen, Peng;Wang, Hong
通讯作者：
Wang, Hong
影响因子：
4.5
作者：
Donner, Thomas W.;Magder, Laurence S.;Zarbalian, Kiarash
通讯作者：
Zarbalian, Kiarash