Sugar-sweetened beverages and risk of obesity and type 2 diabetes: epidemiologic evidence.
Sugar-sweetened beverages and risk of obesity and type 2 diabetes: epidemiologic evidence.
复制标题
DOI：
10.1016/j.physbeh.2010.01.036
复制
发表时间：
2010-04-26
影响因子：
2.9
通讯作者：
Malik, Vasanti S.
中科院分区：
文献类型：
--
作者：
Hu, Frank B.;Malik, Vasanti S.
近几十年来，SSB摄入的时间模式显示出肥胖激增和SSB消费水平上升之间的密切平行关系。ssb是含有添加热量甜味剂的饮料，如蔗糖、高果糖玉米糖浆或浓缩果汁，所有这些都会导致类似的代谢影响。它们包括各种软饮料、碳酸软饮料、水果饮料、水果饮料、运动饮料、能量和维生素水饮料、加糖冰茶、甜酒、南瓜和柠檬水，这些都是美国添加糖摄入量的最大来源。长期以来，人们一直怀疑SSB在肥胖流行中具有病因学作用，但直到最近才有大型流行病学研究能够量化SSB摄入与长期体重增加、2型糖尿病（T2DM）和心血管疾病（CVD）风险之间的关系。实验研究为潜在的潜在生物学机制提供了重要的见解。据认为，SSBs导致体重增加的部分原因是在摄入液体卡路里后的后续膳食中不完全补偿能量。它们还可能增加T2DM和CVD的风险，因为它们是高饮食血糖负荷导致炎症、胰岛素抵抗和β细胞功能受损的一个因素。这些饮料中果糖部分的额外代谢作用也可能促进内脏脂肪的积累，增加肝脏新生脂肪生成，以及高尿酸血症引起的高血压。因此，应以水等健康替代品取代对SSBs的消费，以减少肥胖和慢性病的风险。
In recent decades, temporal patterns in SSB intake have shown a close parallel between the upsurge in obesity and rising levels of SSB consumption. SSBs are beverages that contain added caloric sweeteners such as sucrose, high-fructose corn syrup or fruit-juice concentrates, all of which result in similar metabolic effects. They include the full spectrum of soft drinks, carbonated soft drinks, fruitades, fruit drinks, sports drinks, energy and vitamin water drinks, sweetened iced tea, cordial, squashes, and lemonade, which collectively are the largest contributor to added sugar intake in the US. It has long been suspected that SSBs have an etiologic role in the obesity epidemic, however only recently have large epidemiological studies been able to quantify the relationship between SSB consumption and long-term weight-gain, type 2 diabetes (T2DM) and cardiovascular disease (CVD) risk. Experimental studies have provided important insight into potential underlying biological mechanisms. It is thought that SSBs contribute to weight gain in part by incomplete compensation for energy at subsequent meals following intake of liquid calories. They may also increase risk of T2DM and CVD as a contributor to a high dietary glycemic load leading to inflammation, insulin resistance and impaired β-cell function. Additional metabolic effects from the fructose fraction of these beverages may also promote accumulation of visceral adiposity, and increased hepatic de novo lipogenesis, and hypertension due to hyperuricemia. Consumption of SSBs should therefore be replaced by healthy alternatives such as water, to reduce risk of obesity and chronic diseases.
登录
查看更多内容
影响因子：
16.2
作者：
Bazzano LA;Li TY;Joshipura KJ;Hu FB
通讯作者：
Hu FB
影响因子：
6.9
作者：
Duffey, Kiyah J.;Popkin, Barry M.
通讯作者：
Popkin, Barry M.
DOI：
10.1080/07315724.2005.10719449
发表时间：
2005-04-01
影响因子：
3.5
作者：
Blum, JW;Jacobsen, DJ;Donnelly, JE
通讯作者：
Donnelly, JE
影响因子：
8
作者：
Ebbeling, CB;Feldman, HA;Ludwig, DS
通讯作者：
Ludwig, DS
影响因子：
16.2
作者：
Cowie CC;Rust KF;Ford ES;Eberhardt MS;Byrd-Holt DD;Li C;Williams DE;Gregg EW;Bainbridge KE;Saydah SH;Geiss LS
通讯作者：
Geiss LS