Pretreatment peripheral neutrophils, lymphocytes and monocytes predict long-term survival in hepatocellular carcinoma.
Pretreatment peripheral neutrophils, lymphocytes and monocytes predict long-term survival in hepatocellular carcinoma.
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DOI：
10.1186/s12885-020-07105-8
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发表时间：
2020-09-29
期刊：
影响因子：
3.8
通讯作者：
Cho M
中科院分区：
文献类型：
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作者：
Hong YM;Yoon KT;Hwang TH;Cho M
肝细胞癌（HCC）是一种炎症相关的癌症，其中未消退的炎症有助于其发展和进展。外周炎性细胞已被证明与各种类型的癌症的预后相关。本研究探讨了预处理外周血炎性细胞在肝癌患者预后中的作用。我们回顾性分析了2008年11月至2018年3月期间诊断的HCC患者的外周炎性细胞、患者和肿瘤特征的数据。治疗前记录基线数据，包括外周炎性细胞计数。评估总生存期（OS）与研究变量之间的关系。共纳入1681例诊断为HCC的患者。单因素和多因素分析发现，单个中性粒细胞、淋巴细胞和单核细胞计数是OS不良的独立指标，高中性粒细胞（≥3100 × 106/L）、单核细胞（≥470 × 106/L）计数和低淋巴细胞计数（< 1640 × 106/L）与OS降低显著相关（p < 0.05）。随着巴塞罗那临床肝癌分期的进展，中性粒细胞和单核细胞计数升高，淋巴细胞计数降低（P < 0.001）。治疗前外周血中性粒细胞、淋巴细胞和单核细胞与HCC患者的预后独立相关。这些细胞提供了一种非侵入性，低成本，简单和可重复的生物标志物，可用于常规临床实践，以预测HCC患者的预后。
Hepatocellular carcinoma (HCC) is an inflammation-related cancer, where nonresolving inflammation contributes to its development and progression. Peripheral inflammatory cells have been shown to be associated with the prognosis of various types of cancer. The present study investigated the utility of pretreatment peripheral inflammatory cells in the prognosis of patients with HCC. We retrospectively analyzed data regarding peripheral inflammatory cell, and patient and tumor characteristics from patients with HCC who were diagnosed between November 2008 and March 2018. Baseline data, including peripheral inflammatory cell counts, were recorded before treatment. The relationships between overall survival (OS) and study variables were assessed. A total of 1681 patients who were diagnosed with HCC were included. In univariate and multivariate analyses, individual neutrophil, lymphocyte and monocyte cell counts were found as independent indicators of poor OS. High neutrophil (≥3100 × 106/L) and, monocyte (≥470 × 106/L) counts and low lymphocyte counts (< 1640 × 106/L) significantly associated with reduced OS (p < 0.05). Neutrophil and, monocyte cell counts rose and lymphocyte counts decreased in association with advancing the Barcelona Clinic Liver Cancer stage (P < 0.001). Pretreatment peripheral neutrophils, lymphocytes, and monocytes are independently associated with outcomes of patients with HCC. These cells provides a noninvasive, low-cost, easy, and reproducible biomarker that can be used in routine clinical practice to predict the prognosis of patients with HCC.
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影响因子：
11.2
作者：
Hoshida Y;Nijman SM;Kobayashi M;Chan JA;Brunet JP;Chiang DY;Villanueva A;Newell P;Ikeda K;Hashimoto M;Watanabe G;Gabriel S;Friedman SL;Kumada H;Llovet JM;Golub TR
通讯作者：
Golub TR
影响因子：
64.5
作者：
Gosselin D;Link VM;Romanoski CE;Fonseca GJ;Eichenfield DZ;Spann NJ;Stender JD;Chun HB;Garner H;Geissmann F;Glass CK
通讯作者：
Glass CK
影响因子：
25.7
作者：
Chevret, S;Trinchet, JC;Chastang, C
通讯作者：
Chastang, C
影响因子：
7.2
作者：
Bindea G;Mlecnik B;Angell HK;Galon J
通讯作者：
Galon J
影响因子：
30.5
作者：
通讯作者：
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