Dietary flavonol epicatechin prevents the onset of type 1 diabetes in nonobese diabetic mice.
Dietary flavonol epicatechin prevents the onset of type 1 diabetes in nonobese diabetic mice.
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DOI：
10.1021/jf304915h
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发表时间：
2013-05-08
影响因子：
6.1
通讯作者：
Liu D
中科院分区：
文献类型：
--
作者：
Fu Z;Yuskavage J;Liu D
1型糖尿病（T1 D）是一种自身免疫性疾病，其特征在于胰腺β细胞的选择性破坏。虽然成功的胰岛移植提供了一个有前途的治疗，高成本，缺乏供体器官，免疫介导的破坏移植胰岛，免疫抑制药物的副作用大大限制了它的使用。因此，寻找能够预防或改善T1 D的新型且具有成本效益的药物对于减少T1 D的负担是极其重要的。在这项研究中，我们发现表儿茶素（EC，饮用水中0.5%），一种主要存在于可可中的黄酮醇，有效地预防了非肥胖糖尿病（NOD）小鼠的T1 D。在32周龄时，66.7%的对照组小鼠患有明显的糖尿病，而EC治疗组小鼠只有16.6%患糖尿病。一致的是，EC小鼠具有显著更高的血浆胰岛素水平，但较低的糖化血红蛋白浓度相比，对照组小鼠。EC对NOD小鼠的食物或水摄入量和体重增加没有显着影响，这表明EC的影响不是由于这些变量的改变。EC治疗可提高循环中抗炎细胞因子白细胞介素-10水平，改善胰岛炎，并改善胰岛质量。这些发现表明，EC可能是一种新型的植物源性化合物，能够通过调节免疫功能来预防T1 D，从而保护胰岛质量。
Type 1 diabetes (T1D) is an autoimmune disease characterized by the selective destruction of pancreatic β-cells. Although successful islet transplantation provides a promising treatment, high cost, lack of donor organs, immune-mediated destruction of transplanted islets, and side effects from immunosuppressive drugs greatly limit its uses. Therefore, the search for novel and cost-effective agents that can prevent or ameliorate T1D is extremely important to decrease the burden of T1D. In this study, we discovered that epicatechin (EC, 0.5% in drinking water), a flavonol primarily in cocoa, effectively prevented T1D in non-obese diabetic (NOD) mice. At 32 weeks of age, 66.7% control mice had overt diabetes, whereas only 16.6% EC-treated mice became diabetic. Consistently, EC mice had significantly higher plasma insulin levels but lower glycosylated hemoglobin concentrations compared to control mice. EC had no significant effects on food or water intake and body weight gain in NOD mice, suggesting that EC’s effect was not due to alterations in these variables. Treatment with EC elevates circulating anti-inflammatory cytokine interleukin-10 levels, ameliorates pancreatic insulitis, and improved pancreatic islet mass. These findings demonstrate that EC may be a novel, plant-derived compound capable of preventing T1D by modulating immune function and thereby preserving islet mass.
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DOI：
10.4103/0973-3930.45271
发表时间：
2008-10
影响因子：
0.9
作者：
Aldasouqi SA;Solomon DJ;Bokhari SA;Khan PM;Muneera S;Gossain VV
通讯作者：
Gossain VV
DOI：
10.1093/jn/138.9.1677
发表时间：
2008-09
期刊：
The Journal of nutrition
影响因子：
--
作者：
Bose M;Lambert JD;Ju J;Reuhl KR;Shapses SA;Yang CS
通讯作者：
Yang CS
影响因子：
5.1
作者：
Koh, JJ;Ko, KS;Kim, SW
通讯作者：
Kim, SW
影响因子：
--
作者：
Fraga, Cesar G;Actis-Goretta, Lucas;Ottaviani, Javier I;Carrasquedo, Fernando;Lotito, Silvina B;Lazarus, Sheryl;Schmitz, Harold H;Keen, Carl L
通讯作者：
Keen, Carl L
影响因子：
7.1
作者：
Holt, RR;Lazarus, SA;Keen, CL
通讯作者：
Keen, CL