Reduced hippocampal CA2, CA3, and dentate gyrus activity in asymptomatic people at genetic risk for Alzheimer's disease.
Reduced hippocampal CA2, CA3, and dentate gyrus activity in asymptomatic people at genetic risk for Alzheimer's disease.
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DOI：
10.1016/j.neuroimage.2009.12.014
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发表时间：
2010-11-15
期刊：
影响因子：
5.7
通讯作者：
Bookheimer, Susan Y.
中科院分区：
文献类型：
--
作者：
Suthana, Nanthia A.;Krupa, Allison;Donix, Markus;Burggren, Alison;Ekstrom, Arne D.;Jones, Michael;Ercoli, Linda M.;Miller, Karen J.;Siddarth, Prabha;Small, Gary W.;Bookheimer, Susan Y.
先前针对具有阿尔茨海默病载脂蛋白E4（APOE - 4）遗传风险的健康受试者进行的功能性磁共振成像（MRI）研究表明，在广泛分布的皮质区域进行记忆任务时，其大脑激活程度增加。这些发现被假设反映了完整大脑区域的代偿性募集，这可能是由反映早期疾病的细微神经功能障碍导致的。在这项研究中，我们对APOE - 4携带者和非携带者使用高分辨率功能性MRI来测量海马亚区（CA1、CA2、CA3区；齿状回[DG]和下托）以及相邻的内侧颞叶（海马旁回和内嗅皮层）亚区的活动。我们发现，在认知功能完整的APOE - 4携带者中，左侧CA2、CA3和齿状回（CA23DG）的活动减少。这些结果表明，在出现认知缺陷之前，具有阿尔茨海默病遗传风险的人群中，海马亚区神经活动的减少可能是海马外活动代偿性增加的基础。
Previous functional magnetic resonance imaging (MRI) studies in healthy subjects with the apolipoprotein E 4 (APOE-4) genetic risk for Alzheimer’s disease have shown increased activation during memory task performance in broadly distributed cortical regions. These findings have been hypothesized to reflect compensatory recruitment of intact brain regions that presumably result from subtle neural dysfunction reflecting incipient disease. In this study, we used high-resolution functional MRI in APOE-4 carriers and non-carriers to measure activity in hippocampal subregions (CA fields 1, 2, 3; dentate gyrus [DG], and subiculum) and adjacent medial temporal lobe (parahippocampal and entorhinal) subregions. We found reduced left CA2, 3 and dentate gyrus (CA23DG) activity in cognitively intact APOE-4 carriers. These results suggest that reduced neural activity in hippocampal subregions may underlie the compensatory increase in extra hippocampal activity in people with a genetic risk for Alzheimer’s disease prior to the onset of cognitive deficits.
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