Polarity-dependent transcranial direct current stimulation effects on central auditory processing.
Polarity-dependent transcranial direct current stimulation effects on central auditory processing.
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DOI：
10.1371/journal.pone.0025399
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Boggio PS
中科院分区：
文献类型：
--
作者：
Ladeira A;Fregni F;Campanhã C;Valasek CA;De Ridder D;Brunoni AR;Boggio PS
鉴于经颅直流电刺激(Tdcs)促进或抑制神经元加工的极性依赖效应，以及tdcs对音高知觉的影响，我们测试了tdcs对听觉加工时间方面的影响。我们的目标是使用tdcs改变听觉皮质的基线活动，以调节没有听力障碍的健康受试者的听觉处理的时间方面。11名受试者接受2 mA的双侧阳极、阴极和假TDC，按随机和平衡的顺序进行。在刺激前和刺激期间，受试者通过随机差距检测测试(RGDT)进行评估，RGDT是一种测量听觉领域时间处理能力的测试。统计分析表明，在4000赫兹和短声情况下，时间与tDCS条件之间存在显著的交互作用。根据刺激极性的不同，后组测试显示RGDT成绩有显著差异：与基线相比，阳极组提高了22.5%，阴极组降低了54.5%。对于点击，与基准相比，anodal的性能也提高了29.4%。TDC对听觉皮层的活动表现出极性依赖效应，从而对时间分辨率任务绩效产生积极或消极的影响。这些结果鼓励进一步研究中枢听觉处理障碍中的tDCs。
Given the polarity dependent effects of transcranial direct current stimulation (tDCS) in facilitating or inhibiting neuronal processing, and tDCS effects on pitch perception, we tested the effects of tDCS on temporal aspects of auditory processing. We aimed to change baseline activity of the auditory cortex using tDCS as to modulate temporal aspects of auditory processing in healthy subjects without hearing impairment. Eleven subjects received 2mA bilateral anodal, cathodal and sham tDCS over auditory cortex in a randomized and counterbalanced order. Subjects were evaluated by the Random Gap Detection Test (RGDT), a test measuring temporal processing abilities in the auditory domain, before and during the stimulation. Statistical analysis revealed a significant interaction effect of time vs. tDCS condition for 4000 Hz and for clicks. Post-hoc tests showed significant differences according to stimulation polarity on RGDT performance: anodal improved 22.5% and cathodal decreased 54.5% subjects' performance, as compared to baseline. For clicks, anodal also increased performance in 29.4% when compared to baseline. tDCS presented polarity-dependent effects on the activity of the auditory cortex, which results in a positive or negative impact in a temporal resolution task performance. These results encourage further studies exploring tDCS in central auditory processing disorders.
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影响因子：
2.5
作者：
Ceponiene, R.;Cummings, A.;Wulfeck, B.;Ballantyne, A.;Townsend, J.
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