Interplay of two transcription factors for recruitment of the chromatin remodeling complex modulates fungal nitrosative stress response.
Interplay of two transcription factors for recruitment of the chromatin remodeling complex modulates fungal nitrosative stress response.
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招募染色质重塑复合物的两个转录因子的相互作用调节真菌亚硝化应激反应
DOI：
10.1038/s41467-021-22831-8
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发表时间：
2021-05-06
影响因子：
16.6
通讯作者：
Ma Z
中科院分区：
文献类型：
--
作者：
Jian Y;Liu Z;Wang H;Chen Y;Yin Y;Zhao Y;Ma Z
一氧化氮（NO）是一种可扩散的信号分子，调节动物和植物的免疫反应。此外，来自NO的活性氮物种可以通过与微生物细胞组分反应而显示出抗微生物活性，从而导致病原体中的亚硝化应激（NS）。在这里，我们确定FgAreB作为调节剂的NS响应inFusarium graminearum，真菌病原体的谷类作物。FgAreB作为先驱转录因子，在参与NS反应的基因的启动子处募集染色质重塑复合物SWI/SNF，从而促进其转录。FgAreB在真菌感染和生长中起重要作用。此外，我们发现，转录抑制因子（FgIxr 1）竞争与SWI/SNF复合物FgAreB的结合，并负调控NS的反应。反过来，NS促进FgIxr 1的降解，从而增强FgAreB对SWI/SNF复合物的募集。
Nitric oxide (NO) is a diffusible signaling molecule that modulates animal and plant immune responses. In addition, reactive nitrogen species derived from NO can display antimicrobial activities by reacting with microbial cellular components, leading to nitrosative stress (NS) in pathogens. Here, we identify FgAreB as a regulator of the NS response inFusarium graminearum, a fungal pathogen of cereal crops. FgAreB serves as a pioneer transcription factor for recruitment of the chromatin-remodeling complex SWI/SNF at the promoters of genes involved in the NS response, thus promoting their transcription. FgAreB plays important roles in fungal infection and growth. Furthermore, we show that a transcription repressor (FgIxr1) competes with the SWI/SNF complex for FgAreB binding, and negatively regulates the NS response. NS, in turn, promotes the degradation of FgIxr1, thus enhancing the recruitment of the SWI/SNF complex by FgAreB.
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影响因子：
14.9
作者：
Bresnick EH;Katsumura KR;Lee HY;Johnson KD;Perkins AS
通讯作者：
Perkins AS
影响因子：
16.6
作者：
Abe, Yohei;Rozqie, Royhan;Matsumura, Yoshihiro;Kawamura, Takeshi;Nakaki, Ryo;Tsurutani, Yuya;Tanimura-Inagaki, Kyoko;Shiono, Akira;Magoori, Kenta;Nakamura, Kanako;Ogi, Shotaro;Kajimura, Shingo;Kimura, Hiroshi;Tanaka, Toshiya;Fukami, Kiyoko;Osborne, Timothy F.;Kodama, Tatsuhiko;Aburatani, Hiroyuki;Inagaki, Takeshi;Sakai, Juro
通讯作者：
Sakai, Juro
DOI：
10.1073/pnas.1918977117
发表时间：
2020-05-19
影响因子：
11.1
作者：
Ding, Yi;Gardiner, Donald M.;Kazan, Kemal
通讯作者：
Kazan, Kemal
影响因子：
5.6
作者：
Gupta KJ;Igamberdiev AU
通讯作者：
Igamberdiev AU
影响因子：
--
作者：
Chiranand, Wiriya;McLeod, Ian;Gustin, Michael C.
通讯作者：
Gustin, Michael C.