Influence of epidermal growth factor on liver regeneration after partial hepatectomy in rats
Influence of epidermal growth factor on liver regeneration after partial hepatectomy in rats
复制标题
表皮生长因子对大鼠肝部分切除术后肝再生的影响
作者：
P. S. Olsen;S. Boesby;P. Kirkegaard;K. Therkelsen;T. Almdal;S. Poulsen;E. Nexo
探讨表皮生长因子在大鼠肝部分切除后肝再生中的作用。大鼠肝切除70%后，门静脉血中表皮生长因子的浓度与未手术对照组相比无明显变化。肠内滴注表皮生长因子后，门静脉血中可检测到少量的表皮生长因子。布伦纳氏腺和颌下腺分泌表皮生长因子。摘除Brunner‘s腺会减少肝脏再生，而摘除颌下腺对肝脏再生没有影响。表皮生长因子抗血清显著抑制肝再生。口头或S.C.表皮生长因子对肝再生无影响，而表皮生长因子可增强胰岛素和胰升糖素对肝再生的影响。
The role of epidermal growth factor on liver regeneration after partial hepatectomy in rats was investigated. After a 70% hepatectomy in rats, the concentration of epidermal growth factor in portal venous blood was unchanged compared with unoperated controls. However, small amounts of epidermal growth factor could be identified in portal venous blood after intestinal instillation of epidermal growth factor. Brunner's glands and the submandibular glands secrete epidermal growth factor. Extirpation of Brunner's glands decreased liver regeneration, whereas removal of the submandibular glands had no effect on liver regeneration. Epidermal growth factor antiserum reduced liver regeneration significantly. Oral or s.c. administration of epidermal growth factor had no effect on liver regeneration, whereas epidermal growth factor enhanced the effect of insulin and glucagon on liver regeneration.
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大鼠肝脏再生过程中表皮生长因子易位至肝细胞核。
影响因子：
29.4
作者：
Raper,SE;Burwen,SJ;Barker,ME;Jones,AL
通讯作者：
Jones,AL
大鼠肝脏再生过程中表皮生长因子受体数量减少。
DOI：
10.1172/jci110190
发表时间：
1981
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Earp,HS;O'Keefe,EJ
通讯作者：
O'Keefe,EJ
表皮生长因子的肝隔离和胆汁分泌：高容量摄取系统的证据。
DOI：
10.1073/pnas.80.12.3797
发表时间：
1983
影响因子：
11.1
作者：
StHilaire,RJ;Hradek,GT;Jones,AL
通讯作者：
Jones,AL
再生大鼠肝脏：胰岛素和胰高血糖素血清水平和受体结合。
影响因子：
4.8
作者：
Pezzino,V;Vigneri,R;Cohen,D;Goldfine,ID
通讯作者：
Goldfine,ID