Application of the 2017 McDonald criteria in a Chinese population with clinically isolated syndrome
Application of the 2017 McDonald criteria in a Chinese population with clinically isolated syndrome
复制标题
2017年麦克唐纳标准在中国临床孤立综合征人群中的应用
DOI：
10.1177/1756286419898083
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发表时间：
2020-01
影响因子：
5.9
通讯作者：
Ding Mei-Ping
中科院分区：
文献类型：
--
作者：
Zheng Yang;Shen Chun-Hong;Wang Sa;Yang Fan;Cai Meng-Ting;Fang Wei;Zhang Yin-Xi;Ding Mei-Ping
多发性硬化症的诊断标准随着时间的推移而不断发展，最近的是2017年的McDonald标准。缺乏证据证明2017年McDonald标准在亚洲人群中的有效性。因此，本研究旨在评估2017年McDonald标准在中国临床孤立综合征（CIS）患者中的诊断性能。研究方法：本回顾性研究共纳入了2012年至2017年在中国一家三级医院接受初步结果提示CIS的93例患者。对基线和随访数据进行了审查。分别评估了2017年和2010年McDonald标准的诊断性能（灵敏度、特异性、准确性），并进行了生存分析。结果：93例CIS患者中，女性57例（61.3%），中位（四分位距）发病年龄为37（31.3 - 41.8）岁。与2010年迭代相比，2017年McDonald标准显示出更高的灵敏度（75.0% vs 14.6%，p <0.0001），更低的特异性（47.1% vs 100.0%，p <0.05），但总体准确性更高（67.7% vs 36.9%，p <0.0001）。新标准允许在基线时更好地检测MS（40.8%对9.9%，p <0.0001）。结论：2017年McDonald标准比2010年迭代具有更高的灵敏度，但特异性较低。总体而言，它有助于更早和更准确地诊断多发性硬化症的中国患者与CIS。
Background: Diagnostic criteria for multiple sclerosis have evolved over time, with the most recent being the 2017 McDonald criteria. Evidence is lacking regarding the validity of the 2017 McDonald criteria among the Asian population. Therefore, this study aims to evaluate the diagnostic performance of the 2017 McDonald criteria in Chinese patients with clinically isolated syndrome (CIS). Methods: A total of 93 patients with initial findings suggestive of CIS in a tertiary hospital in China from 2012 to 2017 were included in this retrospective study. Baseline and follow-up data were reviewed. Diagnostic performance (sensitivity, specificity, accuracy), was assessed and survival analysis was performed for the 2017 and 2010 McDonald criteria respectively. Results: Among the 93 Chinese patients with CIS, 57 were female (61.3%) and the median (interquartile range) age of onset was 37 (31.3–41.8) years. The 2017 McDonald criteria displayed a higher sensitivity (75.0% versus 14.6%, p < 0.0001), lower specificity (47.1% versus 100.0%, p < 0.05) but an overall higher accuracy (67.7% versus 36.9%, p < 0.0001) when compared with the 2010 iteration. The novel criteria allow for a better detection of MS at baseline (40.8% versus 9.9%, p < 0.0001). Conclusion: The 2017 McDonald criteria had a higher sensitivity but lower specificity than the 2010 iteration. Overall it facilitated an earlier and more accurate diagnosis of multiple sclerosis in Chinese patients with CIS.
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影响因子：
11.2
作者：
POSER, CM;PATY, DW;TOURTELLOTTE, WW
通讯作者：
TOURTELLOTTE, WW
影响因子：
48
作者：
Thompson, Alan J.;Banwell, Brenda L.;Cohen, Jeffrey A.
通讯作者：
Cohen, Jeffrey A.
影响因子：
2
作者：
Jisheng Cui;Niels G. Becker
通讯作者：
Jisheng Cui;Niels G. Becker
影响因子：
11.2
作者：
Polman CH;Reingold SC;Banwell B;Clanet M;Cohen JA;Filippi M;Fujihara K;Havrdova E;Hutchinson M;Kappos L;Lublin FD;Montalban X;O'Connor P;Sandberg-Wollheim M;Thompson AJ;Waubant E;Weinshenker B;Wolinsky JS
通讯作者：
Wolinsky JS
影响因子：
9.9
作者：
Tintore, Mar;Otero-Romero, Susana;Montalban, Xavier
通讯作者：
Montalban, Xavier