The kidneys and aldosterone/mineralocorticoid receptor system in salt-sensitive hypertension.
The kidneys and aldosterone/mineralocorticoid receptor system in salt-sensitive hypertension.
复制标题
盐敏感性高血压中的肾脏和醛固酮/盐皮质激素受体系统。
DOI：
10.1007/s11906-010-0175-6
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发表时间：
2011-04
影响因子：
5.6
通讯作者：
Fujita, Toshiro
中科院分区：
文献类型：
--
作者：
Shibata, Shigeru;Fujita, Toshiro
关键词：
强有力的证据支持醛固酮/盐皮质激素受体 (MR) 系统主导长期血压控制的能力。它也越来越被认为是心血管和肾脏疾病的重要介质，特别是在盐摄入过多的情况下。在患有代谢综合征的亚组中，脂肪细胞衍生的醛固酮释放因子在盐负荷期间导致肾上腺中醛固酮的不适当分泌，导致盐诱发的高血压以及心脏和肾脏损伤的发生。另一方面，新出现的数据表明醛固酮并不是 MR 活动的唯一调节剂。我们已经确定 MR 和小 GTPase Rac1 之间的信号串扰是促进 MR 信号传导的新途径。这种 MR 的局部控制系统也可能与盐敏感性高血压的发病机制有关，未来的研究将阐明醛固酮/MR 级联复杂调节的详细机制。
Strong evidence supports the ability of the aldosterone/mineralocorticoid receptor (MR) system to dominate long-term blood pressure control. It is also increasingly recognized as an important mediator of cardiovascular and renal diseases, particularly in the presence of excessive salt intake. In a subgroup of individuals with metabolic syndrome, adipocyte-derived aldosterone-releasing factors cause inappropriate secretion of aldosterone in the adrenal glands during salt loading, resulting in the development of salt-induced hypertension and cardiac and renal damage. On the other hand, emerging data reveal that aldosterone is not a sole regulator of MR activity. We have identified the signaling crosstalk between MR and small GTPase Rac1 as a novel pathway to facilitate MR signaling. Such a local control system for MR can also be relevant to the pathogenesis of salt-sensitive hypertension, and future studies will clarify the detailed mechanism for the intricate regulation of the aldosterone/MR cascade.
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