Salt-sensitive hypertension: food for thought.
Salt-sensitive hypertension: food for thought.
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盐敏感性高血压：值得深思。
DOI：
10.1161/hypertensionaha.114.04299
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Gomez-Sanchez,EliseP
中科院分区：
文献类型：
--
作者：
Gomez-Sanchez,EliseP
284高血压2015年2月盐在一个物种中的作用，该物种进化为消耗低钠饮食和各种来源的蛋白质，主要是蔬菜，除了新生儿。例如，半胱氨酸是合成关键的抗氧化剂谷胱甘肽所必需的。肠上皮细胞和神经元对半胱氨酸的吸收受到调节。激活μ阿片受体抑制半胱氨酸摄取。肠道微生物将酪蛋白转化为μ阿片受体肽激动剂;与人相比，牛酪蛋白衍生肽对μ阿片受体具有相对较高的亲和力。抑制半胱氨酸的摄取，从而减少谷胱甘肽的合成可以解释更大的炎症和活性氧在酪蛋白喂养的大鼠产生。活性氧的增加会降低S-腺苷甲硫氨酸作为CpG甲基化的甲基供体的可用性，可能无法抑制本研究中发现上调的许多基因的转录。10本研究中的转录组分析清楚地表明了比较不同来源动物的危害。从不同的近交Dahl SS菌落中产生的遗传差异导致的矛盾信息只是一个例子。[11]尽管本研究中SS/Mcw和SS/Crl之间的遗传差异并不影响血压或肾脏病理的盐敏感性，但它们很可能与其他过程密切相关。SS/Mcw基因组已被测序，并在其背景下开发了许多同源和敲除菌株。如果科学界不能再获得亲本菌株，这些重要资源的价值将大大降低。因此，SS/Crl（SS/McwCrl）商业繁殖群应重新衍生，以反映当前SS/Mcw品系的遗传学，然后再继续用作遗传操作SS/Mcw大鼠的野生型。Geurts等人4提出的结果还表明，必须考虑要比较的动物整个生命周期的环境。由于空间限制和群体维护成本，购买野生动物并不罕见。我们现在有充分的证据表明，将来自机构殖民地的转基因动物与商业获得的亲本动物进行比较，这些动物喂养不同的饮食，并受到运输的压力，特别是在脆弱的群体中，
284 Hypertension February 2015 effect of salt in a species that evolved consuming a low sodium diet and protein from a wide variety of sources, primarily vegetable, except as a neonate. For example, cysteine is essential for the synthesis of the crucial antioxidant glutathione. Absorption of cysteine by intestinal epithelial cells and neurons is regulated. Activating the μ opioid receptor inhibits cysteine uptake. Intestinal microbes convert casein to μ opioid receptor peptide agonists; bovine, compared to human, casein-derived peptides have relatively high affinity for the μ opioid receptor. Inhibition of cysteine uptake, thus decreasing glutathione synthesis may explain the greater inflammation and reactive oxygen species generation in the casein-fed rats. Increased reactive oxygen species would decrease the availability of S-adenosyl methionine available as a methyl donor for CpG methylation, possibly failing to suppress transcription of many of the genes found to be upregulated in this study. 10The transcriptome analysis in this study clearly demonstrates hazards of comparing animals from different sources. Contradictory information derived from diverse inbred Dahl SS colonies resulting from genetic differences is but one example. 11 Although the genetic differences identified between the SS/Mcw and SS/Crl in this study did not affect salt sensitivity of the blood pressure or renal pathology, they may well be germane to others processes. The SS/Mcw genome has been sequenced and numerous congenic and knockout strains have been developed on its background. The value of these important resources would be greatly diminished if the parental strain were no longer available to the scientific community. Therefore, the SS/Crl (SS/McwCrl) commercial breeding colony should be rederived to reflect the genetics of the current SS/Mcw strain before its continued use as the wild type for genetically manipulated SS/Mcw rats. The results presented by Geurts et al4 also demonstrate that it is imperative to consider the environment throughout the lives of animals to be compared. Because of space constraints and colony maintenance costs, it is not uncommon to purchase wild-type animals. We now have ample evidence that comparing genetically modified animals from an institutional colony to commercially obtained parental stock fed different diets and subjected to the stress of shipping, particularly at the vulnerable
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对非典型分枝杆菌肺部感染的免疫反应。
DOI：
10.1093/clinids/3.5.981
发表时间：
1981
期刊：
Reviews of infectious diseases
影响因子：
--
作者：
Collins,FM;Watson,SR
通讯作者：
Watson,SR
死于获得性免疫缺陷的同性恋男性中传播了鸟胞内分枝杆菌感染。
DOI：
10.1001/jama.1982.03330220024029
发表时间：
1982
期刊：
JAMA
影响因子：
--
作者：
P. Zakowski;S. Fligiel;O. Berlin;B. Johnson
通讯作者：
B. Johnson
小鼠外周和肠道淋巴细胞对鼠伤寒沙门氏菌的自然和抗体依赖性细胞介导活性。
影响因子：
4.4
作者：
L. Nencioni;L. Villa;Diana Boraschi;B. Berti;N. A. Tagliabue;R. A. Against
通讯作者：
R. A. Against
自然杀伤 (NK) 细胞对新型隐球菌的体外反应性。
DOI：
--
发表时间：
1982
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Murphy,JW;McDaniel,DO
通讯作者：
McDaniel,DO
沙眼 Bour 菌株在 HeLa 229 细胞中诱导干扰素。
DOI：
--
发表时间：
1967
期刊：
American journal of ophthalmology-glaucoma
影响因子：
--
作者：
H. Jenkin;Y. Lu
通讯作者：
Y. Lu