Immune responses to atypical mycobacterial lung infections.
Immune responses to atypical mycobacterial lung infections.
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对非典型分枝杆菌肺部感染的免疫反应。
DOI：
10.1093/clinids/3.5.981
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Watson,SR
中科院分区：
文献类型：
--
作者：
Collins,FM;Watson,SR
各种非典型分枝杆菌在感染这些微生物的无特定病原体B6 D2小鼠的肺、肝和脾中表现出广泛的生长模式。生长从快速消除（完全无毒）到在肺中持续存在，最终导致许多小鼠死亡。需氧激发小鼠T细胞的预先耗竭不影响肺内微生物的生长特征。感染哈巴纳分枝杆菌的小鼠对该生物体的胞质蛋白抗原（CPA）产生早期超敏反应，这种反应随后是持续的无反应状态。在研究过程中，感染猴分枝杆菌的小鼠在任何时候都没有出现可检测到的超敏反应。从感染M.哈巴尼河在细胞暴露于非特异性T细胞有丝分裂原植物血凝素（PHA）后，猿猴的[3 H]胸苷掺入出现早期峰值。当细胞暴露于M的特异性丝裂原CPA时，出现类似的峰。Habana.在感染后期，无反应性的脾细胞暴露于PHA或CPA后没有淋巴细胞转化。T-细胞混合实验，这是之前和之后进行的治疗与抗-Thy 1.2抗血清加补体的细胞从无能的脾脏悬浮液，表明在无能的动物的抑制性T细胞的群体的存在。
Various species of atypical mycobacteria exhibited a wide range of growth patterns in the lung, liver, and spleen of specific pathogen-free B6D2 mice infected with these organisms. The growth varied from rapid elimination (complete avirulence) to a continued persistence in the lung, which eventually resulted in the death of many of the mice. Prior depletion of the T cells of aerogenically challenged mice did not affect the growth characteristics of the organisms within the lungs. Mice infected withMycobacterium habanadeveloped an early hypersensitivity response to the cytoplasmic protein antigens (CPA) of this organism, and this response was followed by a persistent state of anergy. Mice infected withMycobacterium simiaefailed to develop detectable levels of hypersensitivity at any time during the study. Spleen cells taken from mice infected withM. habanaorM. simiaeexhibited an early peak in the incorporation of [3H] thymidine after exposure of the cells to the nonspecific T-cell mitogen phytohemagglutinin (PHA). A similar peak occurred when the cells were exposed to the specific mitogen CPA ofM. habana. Later in the infection, the anergic spleen cells showed no transformation of lymphocytes after exposure to either PHA or CPA. T-cell-mixing experiments, which were carried out both before and after treatment of suspensions of cells from the anergic spleens with anti-Thy 1.2 antiserum plus complement, indicated the presence of a population of suppressor T cells in the anergic animals.
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在小鼠和豚鼠中测量的结核分枝杆菌毒力的比较研究。
DOI：
10.1164/arrd.1969.100.5.631
发表时间：
1969
期刊：
The American review of respiratory disease
影响因子：
--
作者：
F. Collins;M. M. Smith
通讯作者：
M. M. Smith
抑制在免疫调节中的作用。
影响因子：
--
作者：
R. Gershon
通讯作者：
R. Gershon
非结核分枝杆菌和相关疾病。
DOI：
--
发表时间：
2015
期刊：
American Review of Respiratory Disease
影响因子：
--
作者：
E. Wolinsky
通讯作者：
E. Wolinsky
细胞内分枝杆菌引起的肺部疾病。
DOI：
10.1164/arrd.1973.108.3.547
发表时间：
1973
期刊：
The American review of respiratory disease
影响因子：
--
作者：
H. Yeager;Raleigh Jw
通讯作者：
Raleigh Jw
感染、无反应性和细胞介导的免疫。
DOI：
10.1056/nejm197503202921210
发表时间：
1975
期刊：
The New England journal of medicine
影响因子：
--
作者：
F. Kantor
通讯作者：
F. Kantor