Atopic dermatitis in children: clinical features, pathophysiology, and treatment.
Atopic dermatitis in children: clinical features, pathophysiology, and treatment.
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DOI：
10.1016/j.iac.2014.09.008
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发表时间：
2015-02
影响因子：
2.6
通讯作者：
Stone, Kelly D.
中科院分区：
文献类型：
--
作者：
Lyons, Jonathan J.;Milner, Joshua D.;Stone, Kelly D.
特应性皮炎（AD）是一种慢性、复发性、高度过敏性皮肤病，由遗传易感宿主皮肤中上皮屏障破坏和相关免疫失调引起。AD通常发生在幼儿期，具有典型的年龄依赖性分布，通常与IgE升高、外周嗜酸性粒细胞增多和其他过敏性疾病相关。金黄色葡萄球菌定植是常见的，并可能导致疾病进展和严重程度。需要有针对性的治疗来恢复受损的皮肤屏障和控制炎症，以获得中重度疾病患者的最佳结局。瘙痒在AD患者中普遍存在，对生活质量下降具有显著影响。抗组胺药等药物在控制AD相关瘙痒方面的疗效较差。对患者进行关于主要潜在缺陷的教育并提供全面的皮肤护理计划对于疾病维持和耀斑管理至关重要。
Atopic dermatitis (AD) is a chronic, relapsing, highly pruritic skin condition resulting from disruption of the epithelial barrier and associated immune dysregulation in the skin of genetically predisposed hosts. AD generally develops in early childhood, has a characteristic age-dependent distribution and is commonly associated with elevated IgE, peripheral eosinophilia and other allergic diseases. Staphylococcus aureus colonization is common and may contribute to disease progression and severity. Targeted therapies to restore both impaired skin barrier and control inflammation are required for optimal outcomes for patients with moderate to severe disease. Pruritus is universal among patients with AD and has a dominant impact on diminishing quality of life. Medications such as anti-histamines have demonstrated poor efficacy in controlling AD-associated itch. Education of patients regarding the primary underlying defects and provision of a comprehensive skin care plan is essential for disease maintenance and management of flares.
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影响因子：
9.8
作者：
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通讯作者：
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影响因子：
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DOI：
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