Singlet Oxygen Generation Using Thiolated Gold Nanoclusters under Photo- and Ultrasonic Excitation: Size and Ligand Effect
Singlet Oxygen Generation Using Thiolated Gold Nanoclusters under Photo- and Ultrasonic Excitation: Size and Ligand Effect
复制标题
在光和超声波激发下使用硫醇化金纳米团簇产生单线态氧：尺寸和配体效应
DOI：
10.1021/acs.jpcc.2c05404
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Kawasaki Hideya
中科院分区：
文献类型：
--
作者：
Yagi Junichi;Ikeda Atsuya;Wang Liu-Chun;Yeh Chen-Sheng;Kawasaki Hideya
液体的超声辐照可以诱导半导体纳米颗粒中的催化活性（声催化/声敏化），类似于光诱导的光催化/光敏化。然而，由于声催化/声致敏中涉及的声空化过程的复杂性，还没有为它们确定理想的纳米颗粒设计。本文研究了硫醇金纳米团簇（Au NCs）的尺寸和配体依赖性超声活化及其对单线态氧（1 O2）产生的光敏化和声敏化能力。Au NC基光敏化和声增敏之间的差异也阐明了，沿着与后者的机制。对于Au ~（25）NC的声增敏和光敏化，配体对~（10）O_2产生效率的影响顺序为谷胱甘肽<卡托普利< 4-巯基苯甲酸。使用声/光激发的Au 25 NCs的竞争1 O2生产和淬灭反应决定了净1 O2生产。对1 O2-产生效率的尺寸效应的顺序为Au 144 → Au 25>等离子体Au纳米颗粒用于声敏化，而不是光敏化的情况：Au 25 → Au 144 →等离子体Au纳米颗粒。通过超声激发的Au 144 NCs的1 O2生成与高能超声空化相关，取决于超声功率和频率。因此，高能超声空化介导的基于Au 144 NC的声敏剂可以有效地用于生产1 O2，用于各种化学和生物医学应用。
Ultrasonic irradiation of liquids can induce catalytic activity in semiconductor nanoparticles (sonocatalysis/sonosensitization) similar to light-induced photocatalysis/photosensitization. However, due to the complexity of the acoustic cavitation processes involved in sonocatalysis/sonosensitization, an ideal nanoparticle design has not been identified for them. Herein, the size- and ligand-dependent ultrasonic activation of thiolate gold nanoclusters (Au NCs) and their photosensitizing and sonosensitizing abilities for singlet oxygen (1O2) generation were investigated. The difference between Au NC-based photosensitization and sonosensitization was also elucidated, along with a mechanism for the latter. For Au25NC-based sonosensitization and photosensitization, the ligand effect on the1O2-generation efficiency was in the order of glutathione < captopril < 4-mercaptobenzoic acid. The competing1O2production and quenching reactions using sono-/photo-excited Au25NCs determined the net1O2production. The size effects on the1O2-generation efficiency were in the order of Au144≫ Au25> plasmonic Au nanoparticle for sonosensitization, as opposed to the case of photosensitization: Au25≫ Au144∼ plasmonic Au nanoparticle. The1O2generation via ultrasonically excited Au144NCs correlated with high-energy ultrasonic cavitation depending on the ultrasonication power and frequency. Therefore, high-energy ultrasonic cavitation-mediated Au144NC-based sonosensitizers could be effectively used in the production of1O2for various chemical and biomedical applications.
影响因子：
8.4
作者：
Yusof NSM;Anandan S;Sivashanmugam P;Flores EMM;Ashokkumar M
通讯作者：
Ashokkumar M
受硫醇保护的可控直径金纳米粒子的合成与表征
影响因子：
3.7
作者：
L. Shaltiel;Asaf Shemesh;U. Raviv;Y. Barenholz;Y. Levi
通讯作者：
Y. Levi
影响因子：
9.5
作者：
Katla SK;Zhang J;Castro E;Bernal RA;Li X
通讯作者：
Li X