Atomically Precise Au(25)(SG)(18) Nanoclusters: Rapid Single-Step Synthesis and Application in Photothermal Therapy.

Atomically Precise Au(25)(SG)(18) Nanoclusters: Rapid Single-Step Synthesis and Application in Photothermal Therapy.
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DOI:
10.1021/acsami.7b12614
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发表时间:
2018-01-10
影响因子:
9.5
通讯作者:
Li X
Li X
中科院分区:
材料科学2区
文献类型:
--
作者:
Katla SK;Zhang J;Castro E;Bernal RA;Li X

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Au 25(SR)18纳米团簇的最新进展在催化、传感和磁性方面有着重要的应用。然而,现有的合成路线是复杂的,特别是对于水溶性Au 25(SG)18纳米簇。在这里,我们报告了一个单步浓度和温度控制的方法,快速合成的Au 25(SG)18纳米团簇在短短2小时,而不需要低温反应,甚至搅拌。进行了系统的基于时间的调查,以研究这些纳米团簇的合成的体积,浓度和温度的影响。此外,我们首次发现Au 25(SG)18纳米团簇在使用808 nm激光源以10 W/cm 2的功率实现MDAMB-231乳腺癌细胞100%细胞死亡方面表现出优异的光热活性,展示了光热治疗的应用。
Remarkable recent advances on Au25(SR)18 nanoclusters have led to significant applications in catalysis, sensing, and magnetism. However, the existing synthetic routes are complicated, particularly for the water-soluble Au25(SG)18 nanoclusters. Here, we report a single-step concentration and temperature-controlled method for rapid synthesis of the Au25(SG)18 nanoclusters in as little as 2 h without the need for low-temperature reaction or even stirring. A systematic time-based investigation was carried out to study the effects of volume, concentration, and temperature on the synthesis of these nanoclusters. Further, we discovered for the first time that the Au25(SG)18 nanoclusters exhibit excellent photothermal activities in achieving 100% cell death for MDAMB-231 breast cancer cells at a power of 10 W/cm2 using an 808 nm laser source, demonstrating applications toward photothermal therapy.
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