Interactions with stromal cells promote a more oxidized cancer cell redox state in pancreatic tumors.
Interactions with stromal cells promote a more oxidized cancer cell redox state in pancreatic tumors.
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DOI：
10.1126/sciadv.abg6383
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发表时间：
2022-01-21
期刊：
影响因子：
13.6
通讯作者：
Vander Heiden MG
中科院分区：
文献类型：
--
作者：
Datta R;Sivanand S;Lau AN;Florek LV;Barbeau AM;Wyckoff J;Skala MC;Vander Heiden MG
获得电子受体支持氧化生物合成，并可能限制癌细胞的增殖，但癌细胞如何在肿瘤中克服这一限制尚不完全清楚。肿瘤中未转化的细胞可以帮助癌细胞克服代谢限制，特别是在胰腺癌中，胰腺星状细胞(PSCs)促进癌细胞增殖和肿瘤生长。然而，PSCs是否影响癌细胞的氧化还原状态尚不清楚。利用还原烟酰胺腺嘌呤二核苷酸和氧化黄素腺嘌呤二核苷酸辅因子的内源性荧光特性，我们使用光学成像来评估胰腺癌细胞和PSCs的氧化还原状态，发现PSCs与癌细胞之间的直接相互作用促进了癌细胞中更多的氧化状态。这表明癌细胞和PSCs之间的代谢相互作用是克服胰腺癌细胞增殖的氧化还原限制的一种机制。胰腺间质细胞和胰腺癌细胞之间的相互作用影响癌细胞的氧化还原状态。
Access to electron acceptors supports oxidized biomass synthesis and can be limiting for cancer cell proliferation, but how cancer cells overcome this limitation in tumors is incompletely understood. Nontransformed cells in tumors can help cancer cells overcome metabolic limitations, particularly in pancreatic cancer, where pancreatic stellate cells (PSCs) promote cancer cell proliferation and tumor growth. However, whether PSCs affect the redox state of cancer cells is not known. By taking advantage of the endogenous fluorescence properties of reduced nicotinamide adenine dinucleotide and oxidized flavin adenine dinucleotide cofactors we use optical imaging to assess the redox state of pancreatic cancer cells and PSCs and find that direct interactions between PSCs and cancer cells promote a more oxidized state in cancer cells. This suggests that metabolic interaction between cancer cells and PSCs is a mechanism to overcome the redox limitations of cell proliferation in pancreatic cancer. Interactions between pancreatic stromal cells and pancreatic cancer cells affect the redox state of the cancer cells.
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影响因子：
2.2
作者：
Heikal AA
通讯作者：
Heikal AA
影响因子：
14
作者：
Broekgaarden, Mans;Anbil, Sriram;Hasan, Tayyaba
通讯作者：
Hasan, Tayyaba
DOI：
10.1152/ajpendo.00673.2010
发表时间：
2011-07-01
影响因子：
5.1
作者：
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通讯作者：
Heart, Emma
影响因子：
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作者：
Helms E;Onate MK;Sherman MH
通讯作者：
Sherman MH
影响因子：
28.2
作者：
Biffi G;Oni TE;Spielman B;Hao Y;Elyada E;Park Y;Preall J;Tuveson DA
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Tuveson DA