Infusions of bicuculline to the ventral tegmental area attenuates sexual, exploratory, and anti-anxiety behavior of proestrous rats.
Infusions of bicuculline to the ventral tegmental area attenuates sexual, exploratory, and anti-anxiety behavior of proestrous rats.
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DOI：
10.1016/j.pbb.2009.06.012
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发表时间：
2009-10
影响因子：
3.6
通讯作者：
Paris, Jason J.
中科院分区：
文献类型：
--
作者：
Frye, Cheryl A.;Paris, Jason J.
关键词：
5α-孕-3α-醇-20-酮（3α,5α-THP）在中脑腹侧被盖区（VTA）的作用调节雌性大鼠的性接受性。3α，5α-THP作用于VTA中gaba能底物，已知可调节啮齿类动物性行为的完成性方面，如前凸。然而，VTA中的GABAA受体对性接受的食欲（探索性、抗焦虑性、社会性）方面的重要程度尚不清楚。将生理盐水或GABAA受体拮抗剂双cuulline （100 ng）双侧灌注到VTA或缺失部位对照部位。评估大鼠的探索/抗焦虑（开放场地/高架+迷宫），社交（社会互动）和性（节奏交配）行为。与生理盐水或缺失部位对照组相比，vta内双丘碱显著降低了开放区域中央入口的数量、在高架迷宫张开双臂上花费的时间、前凸的频率和强度、对男性的抗攻击性、性接触的起搏率以及中脑和海马中的3α、5α-THP浓度。注射双球茎碱的大鼠也表现出更少的与新同体的联系，更少的性恳求，间脑和皮层的3α，5α-THP浓度降低，尽管这些差异不显著。因此，中脑VTA中GABAA受体的作用对大鼠性接受性的食欲和完满性方面至关重要。
Actions of 5α-pregnan-3α-ol-20-one (3α,5α-THP), in the midbrain ventral tegmental area (VTA) modulate sexual receptivity of female rats. Actions of 3α,5α-THP at GABAergic substrates in the VTA are known to modulate consummatory aspects of sexual behavior among rodents, such as lordosis. However, the extent to which GABAA receptors in the VTA are important for appetitive (exploratory, anti-anxiety, social) aspects of sexual-receptivity is not well-understood. Proestrous rats were bilaterally-infused with saline or bicuculline (100 ng), a GABAA receptor antagonist, to the VTA or missed-site control sites. Rats were assessed for exploratory/anti-anxiety (open field/elevated plus maze), social (social interaction), and sexual (paced-mating) behavior. Compared to saline or missed-site controls, intra-VTA bicuculline significantly reduced the number of central entries in an open field, time spent on the open arms of an elevated plus maze, frequency and intensity of lordosis, anti-aggression towards a male, pacing of sexual contacts, and 3α,5α-THP concentrations in midbrain and hippocampus. Bicuculline-infused rats also displayed less affiliation with a novel conspecific, fewer sexual solicitations, and had lower 3α,5α-THP concentrations in diencephalon and cortex, albeit these were not significant differences. Thus, actions at GABAA receptors in the midbrain VTA are essential for appetitive and consummatory aspects of sexual receptivity among rats.
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DOI：
10.1530/jrf.0.0900375
发表时间：
1990-11-01
期刊：
JOURNAL OF REPRODUCTION AND FERTILITY
影响因子：
--
作者：
FRYE, CA;ERSKINE, MS
通讯作者：
ERSKINE, MS
影响因子：
3.4
作者：
Bitran, D;Foley, M;Frye, CA
通讯作者：
Frye, CA
影响因子：
2.9
作者：
BITRAN, D;HILVERS, RJ;KELLOGG, CK
通讯作者：
KELLOGG, CK
影响因子：
6.1
作者：
ERSKINE, MS;KORNBERG, E
通讯作者：
KORNBERG, E
影响因子：
--
作者：
Frye, CA
通讯作者：
Frye, CA