Comparison of Human Milk Immunoglobulin Survival during Gastric Digestion between Preterm and Term Infants.
Comparison of Human Milk Immunoglobulin Survival during Gastric Digestion between Preterm and Term Infants.
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DOI：
10.3390/nu10050631
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发表时间：
2018-05-17
期刊：
影响因子：
5.9
通讯作者：
Dallas DC
中科院分区：
文献类型：
--
作者：
Demers-Mathieu V;Underwood MA;Beverly RL;Nielsen SD;Dallas DC
母乳提供免疫球蛋白（Ig），补充新生儿的被动免疫系统;然而，这些Ig在胃消化过程中的存活程度以及早产儿和足月儿之间是否存在差异仍然未知。从15对早产儿（23-32周胎龄（GA））母婴对和8对足月儿（38-40周GA）母婴对中采集母乳和摄入后2 h的婴儿胃样本，这些母婴对出生后7-98天内。通过ELISA分析样品的总伊加（分泌型伊加（SIgA）/伊加）、总分泌组分（SC/SIgA/SIgM）、总IgM（SIgM/IgM）和IgG以及肽组的浓度。总伊加浓度下降了60%，从母乳早产儿胃和下降了48%，在足月婴儿胃。总IgM和IgG浓度下降了33%和77%，分别从人乳到足月婴儿胃，但在早产儿胃是稳定的。从所有IG同种型释放的肽在足月婴儿胃高于早产儿胃。总体而言，早产儿母乳Ig在胃消化过程中的稳定性高于足月儿，这可能有助于早产儿未成熟的免疫系统。
Human milk provides immunoglobulins (Igs) that supplement the passive immune system of neonates; however, the extent of survival of these Igs during gastric digestion and whether this differs between preterm and term infants remains unknown. Human milk, and infant gastric samples at 2 h post-ingestion were collected from 15 preterm (23–32 week gestational age (GA)) mother-infant pairs and from 8 term (38–40 week of GA) mother-infant pairs within 7–98 days postnatal age. Samples were analyzed via ELISA for concentration of total IgA (secretory IgA (SIgA)/IgA), total secretory component (SC/SIgA/SIgM), total IgM (SIgM/IgM), and IgG as well as peptidomics. Total IgA concentration decreased by 60% from human milk to the preterm infant stomach and decreased by 48% in the term infant stomach. Total IgM and IgG concentrations decreased by 33% and 77%, respectively, from human milk to the term infant stomach but were stable in the preterm infant stomach. Release of peptides from all Ig isotypes in the term infant stomach was higher than in the preterm stomach. Overall, the stability of human milk Igs during gastric digestion is higher in preterm infant than in term infants, which could be beneficial for assisting the preterm infants’ immature immune system.
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影响因子：
2.3
作者：
Faingold, Ricardo;Cassia, Guilherme;Sant'Anna, Guilherme M.
通讯作者：
Sant'Anna, Guilherme M.
DOI：
10.1152/ajpgi.00021.2006
发表时间：
2006-07-01
影响因子：
4.5
作者：
Hansen, Gert H.;Niels-Christiansen, Lise-Lotte;Danielsen, E. Michael
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Danielsen, E. Michael
DOI：
10.1097/mpg.0000000000001719
发表时间：
2018-02-01
影响因子：
2.9
作者：
Demers-Mathieu, Veronique;Nielsen, Soren Drud;Dallas, David C.
通讯作者：
Dallas, David C.
影响因子：
3.6
作者：
GOLDBLUM, RM;SCHANLER, RJ;GOLDMAN, AS
通讯作者：
GOLDMAN, AS
DOI：
10.1177/039463200702000114
发表时间：
2007-01-01
影响因子：
3.5
作者：
Ballabio, C.;Bertino, E.;Restani, P.
通讯作者：
Restani, P.