High expression of SPP1 in patients with chronic obstructive pulmonary disease (COPD) is correlated with increased risk of lung cancer.
High expression of SPP1 in patients with chronic obstructive pulmonary disease (COPD) is correlated with increased risk of lung cancer.
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慢性阻塞性肺疾病（COPD）患者中SPP1的高表达与肺癌风险增加相关
DOI：
10.1002/2211-5463.13127
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发表时间：
2021-04
期刊：
影响因子：
2.6
通讯作者：
Fu JJ
中科院分区：
文献类型：
--
作者：
Miao TW;Xiao W;Du LY;Mao B;Huang W;Chen XM;Li C;Wang Y;Fu JJ
慢性阻塞性肺疾病（COPD）的特征是持续的气道炎症和固定的气流阻塞。COPD患者患肺癌（LC）的风险增加，两种疾病的共存与生存率降低相关。然而，导致COPD患者发生LC和预后不良的机制尚不清楚。基因表达谱从Gene Expression Omnibus下载。纳入了22个数据集（n = 876）。我们确定了133 DEG和145 DEG的COPD和LC患者与健康对照组相比，分别。与COPD患者相比，LC合并COPD患者有1544个DEG，这些DEG主要参与细胞周期、DNA复制、p53信号和胰岛素信号。与这些DEG相关的生物学过程主要是氧化还原和细胞凋亡。SPP 1是COPD和/或LC患者中唯一上调的重叠DEG，这在一个独立队列中通过qPCR进行了验证。SPP 1预测COPD患者LC的曲线下面积为0.893（0.822-0.963）。SPP 1在LC患者中的高表达与较短的生存时间相关。SPP 1的上调可能与COPD患者LC风险增加相关，因此可能成为COPD患者LC的治疗靶点。
Chronic obstructive pulmonary disease (COPD) is characterized by persistent airway inflammation and fixed airflow obstruction. Patients with COPD have increased risk of lung cancer (LC), and the coexistence of both diseases is associated with poorer survival. However, the mechanisms predisposing patients with COPD to LC development and poor prognosis remain unclear. Gene expression profiles were downloaded from the Gene Expression Omnibus. Twenty‐two data sets were included (n = 876). We identified 133 DEGs and 145 DEGs in patients with COPD and LC compared with healthy controls, respectively. There were 1544 DEGs in patients with LC and coexisting COPD compared with COPD, and these DEGs are mainly involved in the cell cycle, DNA replication, p53 signalling and insulin signalling. The biological processes primarily associated with these DEGs are oxidation reduction and apoptosis. SPP1 was the only overlapping DEG that was up‐regulated in patients with COPD and/or LC, and this was validated by qPCR in an independent cohort. The area under the curve value for SPP1 was 0.893 (0.822–0.963) for the prediction of LC in patients with COPD. High expression of SPP1 in patients with LC was associated with shorter survival time. Up‐regulation of SPP1 may be associated with increased risk of LC in patients with COPD and therefore may have potential as a therapeutic target for LC in patients with COPD.
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影响因子：
5.7
作者：
Li W;Zheng G;Xia J;Yang G;Sun J;Wang X;Wen M;Sun Y;Zhang Z;Jin F
通讯作者：
Jin F
影响因子：
5.3
作者：
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作者：
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通讯作者：
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影响因子：
4.3
作者：
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通讯作者：
MUERS, MF