Standardized Phase Angle for Predicting Nutritional Status of Hemodialysis Patients in the Early Period After Deceased Donor Kidney Transplantation.
Standardized Phase Angle for Predicting Nutritional Status of Hemodialysis Patients in the Early Period After Deceased Donor Kidney Transplantation.
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DOI：
10.3389/fnut.2022.803002
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发表时间：
2022
影响因子：
5
通讯作者：
Miglinas M
中科院分区：
文献类型：
--
作者：
Sukackiene D;Rimsevicius L;Miglinas M
本研究旨在验证移植后早期标准化相位角（SPhA）是否决定了血液透析患者在不同营养指标方面的营养状况，并预测肾移植后6个月的握力（HGS）。共有82名接受维持性血液透析治疗的肾移植受者进入研究。分别在肾移植前、出院时和移植后6个月评估营养状况。我们使用了生物电阻抗分析（BIA）、三种不同的营养不良筛查工具、HGS和人体测量。收集人口统计资料和生化营养指标。SPhA值经年龄和BMI调整后用于我们的研究。在移植后早期，肾移植受者肌肉量减少，脂肪量增加，SPhA大多呈阴性，同时白蛋白水平显著降低。sphadi低于中位数（<-1.46）的受试者[根据住院时间和基线SPhA调整的出院时SPhA]表现出较低的白蛋白浓度（43.4比45.1 g/l, p = 0.010）、血红蛋白（124比133 g/l， p = 0.016）、GNRI（113比118，p = 0.041）和HGS（30比33 kg， p = 0.043）。这些患者的铁蛋白浓度较高（420比258 mkmol/l， p = 0.026），住院时间较长（32比21天，p < 0.001）， MIS评分较高（3比1，p = 0.001）。在出院时，低于中位数的SPhA与蛋白质能量浪费有关，表现为较低的营养生物标志物浓度和活跃的炎症反应。肾移植前较高的SPhA预示着肾移植后6个月的HGS，尤其是女性。
This study was designed to verify whether early posttransplant standardized phase angle (SPhA) determines nutrition status of hemodialysis patients in regard to different nutritional markers and predicts handgrip strength (HGS) 6 months after kidney transplantation. A total of 82 kidney transplant recipients on maintenance hemodialysis treatment entered the study. Nutritional status was evaluated before kidney transplantation, at the hospital discharge date, and 6 months after. We used bioelectrical impedance analysis (BIA), three different malnutrition screening tools, HGS, and anthropometric measurements. Demographic profiles and biochemical nutritional markers were collected. SPhA values, adjusted for age and BMI, were used in our study. In the early posttransplant period, kidney transplant recipients lost muscle mass, gained fat mass, and developed mostly negative SPhA, accompanied by significantly lower albumin levels. The subjects with lower than median (<-1.46) SPhAdis [the SPhA (at discharge) adjusted for hospitalization time and the baseline SPhA] displayed lower values of albumin concentration (43.4 vs. 45.1 g/l, p = 0.010), hemoglobin (124 vs. 133 g/l, p = 0.016), GNRI (113 vs. 118, p = 0.041), and HGS (30 vs. 33 kg, p = 0.043). These patients had higher ferritin concentrations (420 vs. 258 mkmol/l, p = 0.026), longer inpatient stays (32 vs. 21 days, p < 0.001), and higher MIS scores (3 vs. 1, p = 0.001). At the moment of hospital discharge, lower than the median SPhA is related to protein-energy wasting, represented as lower concentrations of nutrition biomarkers and an active inflammatory response. Higher SPhA before kidney transplantation predicts HGS 6 months after kidney transplantation, especially in women.
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影响因子：
5.4
作者：
Mullie L;Obrand A;Bendayan M;Trnkus A;Ouimet MC;Moss E;Chen-Tournoux A;Rudski LG;Afilalo J
通讯作者：
Afilalo J
影响因子：
3.9
作者：
Nolte Fong JV;Moore LW
通讯作者：
Moore LW
影响因子：
3.4
作者：
Mueller, Charles;Compher, Charlene;Ellen, Druyan Mary
通讯作者：
Ellen, Druyan Mary
影响因子：
3.4
作者：
Bosy-Westphal, Anja;Danielzik, Sandra;Mueller, Manfred J.
通讯作者：
Mueller, Manfred J.
影响因子：
6.3
作者：
Ringaitiene, Donata;Gineityte, Dalia;Ivaskevicius, Juozas
通讯作者：
Ivaskevicius, Juozas