Colonocyte metabolism shapes the gut microbiota.
Colonocyte metabolism shapes the gut microbiota.
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DOI：
10.1126/science.aat9076
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发表时间：
2018-11-30
期刊：
影响因子：
--
通讯作者：
Bäumler AJ
中科院分区：
文献类型：
--
作者：
Litvak Y;Byndloss MX;Bäumler AJ
结肠微生物群的不平衡可能是任何人类疾病的基础，但维持体内平衡的机制仍然难以捉摸。最近的见解表明，结肠细胞代谢功能作为一个控制开关，介导的稳态和生态失调的社区之间的转变。在体内平衡期间，结肠细胞代谢直接朝向氧化磷酸化，导致高上皮氧消耗。随之而来的上皮缺氧有助于维持由专性厌氧细菌主导的微生物群落，这些细菌通过将纤维转化为宿主吸收的发酵产物来提供益处。改变结肠上皮细胞基质的条件增加上皮细胞的氧合，从而驱动兼性厌氧菌的扩增，这是结肠中生态失调的标志。肠道病原体破坏结肠细胞代谢以逃避肠道微生物群赋予的生态位保护。相反的策略，代谢重编程以恢复结肠细胞缺氧，代表了一种有前途的新的治疗方法，用于在广泛的人类疾病中重新平衡结肠微生物群。结肠上皮细胞的能量代谢充当肠道微生物群的控制开关，介导稳态和生态失调群落之间的转变。
An imbalance in the colonic microbiota might underlie m any hum an diseases, but the mechanisms maintaining homeostasis remain elusive. Recent insights suggest that colonocyte metabolism functions as a control switch, mediating a shift between homeostatic and dysbiotic communities. During homeostasis, colonocyte metabolism is directed towards oxidative phosphorylation, resulting in high epithelial oxygen consumption. The consequent epithelial hypoxia helps maintain a microbial com m unity dominated by obligate anaerobic bacteria, which provide benefit by converting fiber into fermentation products absorbed by the host. Conditions that alter the m etabolism of the colonic epithelium increase epithelial oxygenation, thereby driving an expansion of facultative anaerobic bacteria, a hallmark of dysbiosis in the colon. Enteric pathogens subvert colonocyte metabolism to escape niche protection conferred by the gut microbiota. The reverse strategy, a m etabolic reprogramming to restore colonocyte hypoxia, represents a promising new therapeutic approach for rebalancing the colonic microbiota in a broad spectrum of hum an diseases. The energy metabolism of colonic epithelial cells functions as a control switch of the gut microbiota, mediating shifts between homeostatic and dysbiotic communities.
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影响因子：
29
作者：
Donohoe DR;Garge N;Zhang X;Sun W;O'Connell TM;Bunger MK;Bultman SJ
通讯作者：
Bultman SJ
DOI：
10.1126/science.aam9949
发表时间：
2017-08-11
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Byndloss MX;Olsan EE;Rivera-Chávez F;Tiffany CR;Cevallos SA;Lokken KL;Torres TP;Byndloss AJ;Faber F;Gao Y;Litvak Y;Lopez CA;Xu G;Napoli E;Giulivi C;Tsolis RM;Revzin A;Lebrilla CB;Bäumler AJ
通讯作者：
Bäumler AJ
影响因子：
64.8
作者：
Devkota, Suzanne;Wang, Yunwei;Musch, Mark W.;Leone, Vanessa;Fehlner-Peach, Hannah;Nadimpalli, Anuradha;Antonopoulos, Dionysios A.;Jabri, Bana;Chang, Eugene B.
通讯作者：
Chang, Eugene B.
影响因子：
30.3
作者：
Bronner DN;Faber F;Olsan EE;Byndloss MX;Sayed NA;Xu G;Yoo W;Kim D;Ryu S;Lebrilla CB;Bäumler AJ
通讯作者：
Bäumler AJ
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K