Unusually long palindromes are abundant in mitochondrial control regions of insects and nematodes.
Unusually long palindromes are abundant in mitochondrial control regions of insects and nematodes.
复制标题
在昆虫和线虫的线粒体控制区域中，异常长的腔素很长。
DOI：
10.1371/journal.pone.0000110
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发表时间：
2006-12-20
期刊：
影响因子：
3.7
通讯作者：
Nagaraju J
中科院分区：
文献类型：
--
作者：
Arunkumar KP;Nagaraju J
已知回文酶参与多种生物过程。在本研究中，我们进行了全面的分析回文在几个动物群体的线粒体控制区（CRs），研究其频率，分布和架构，以了解线粒体DNA的复制起点。许多节肢动物、线虫、软体动物和环节动物的CRs中都含有回文序列和反向重复序列。低等动物如刺胞动物和高等动物如脊索动物几乎没有回文和IR。研究表明，回文出现与CR的AT含量呈正相关，IR可能会产生较长的回文。本研究试图解释可能的原因，并提供在计算机模拟证据，回文和IR的脊椎动物线粒体DNA的CR和收购和保留相同的。对不同动物门的CRs的研究揭示了该基因座的独特结构，无论是在昆虫门和线虫门的CRs中高丰度的长回文序列和IR，还是在螯肢亚门中具有10-20个核苷酸的短IR和12-14个碱基的间隔区，或者在脊椎动物门、刺胞动物门和棘皮动物门中几乎完全不存在任何长回文序列和IR。
Palindromes are known to be involved in a variety of biological processes. In the present investigation we carried out a comprehensive analysis of palindromes in the mitochondrial control regions (CRs) of several animal groups to study their frequency, distribution and architecture to gain insights into the origin of replication of mtDNA. Many species of Arthropoda, Nematoda, Mollusca and Annelida harbor palindromes and inverted repeats (IRs) in their CRs. Lower animals like cnidarians and higher animal groups like chordates are almost devoid of palindromes and IRs. The study revealed that palindrome occurrence is positively correlated with the AT content of CRs, and that IRs are likely to give rise to longer palindromes. The present study attempts to explain possible reasons and gives in silico evidence for absence of palindromes and IRs from CR of vertebrate mtDNA and acquisition and retention of the same in insects. Study of CRs of different animal phyla uncovered unique architecture of this locus, be it high abundance of long palindromes and IRs in CRs of Insecta and Nematoda, or short IRs of 10–20 nucleotides with a spacer region of 12–14 bases in subphylum Chelicerata, or nearly complete of absence of any long palindromes and IRs in Vertebrata, Cnidaria and Echinodermata.
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影响因子：
2.6
作者：
Dotson, EM;Beard, CB
通讯作者：
Beard, CB
影响因子：
3.3
作者：
Albrecht, EB;Hunyady, AB;Patterson, TE
通讯作者：
Patterson, TE
影响因子：
5.6
作者：
DESJARDINS, P;MORAIS, R
通讯作者：
MORAIS, R
影响因子：
5.4
作者：
Cheung, AK
通讯作者：
Cheung, AK
DOI：
10.1073/pnas.78.1.459
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
EGNER, C;BERG, DE
通讯作者：
BERG, DE