Simulated Colonic Feces Reveals Novel Contraction Patterns.
Simulated Colonic Feces Reveals Novel Contraction Patterns.
复制标题
DOI：
10.1053/j.gastro.2020.09.055
复制
发表时间：
2021-02
期刊：
影响因子：
29.4
通讯作者：
中科院分区：
文献类型：
--
作者：
结肠内容物的运输是一个复杂的生理过程，内容物从回肠接收，在结肠通道中凝固，最后通过肛门从直肠排出。1,2在机械负荷和运动需要量化的情况下，结肠的运动和转运是难以研究的。自1902年Cannon的经典放射摄影作品以来，人们已经知道反蠕动是结肠运动的共同特征。最近，由Cajal间质细胞和时空直径图上的波纹产生的潜在慢波模式已经在体外描述。由于缺乏测量生理和病理生理过程的技术，结肠运动的许多方面仍未被探索。在病理生理学上，便秘影响了高达25%的人口，但仍然缺乏认识和治疗。4,5区分慢传输型便秘和排便障碍是很重要的。严重的慢传输型便秘患者可能适合进行全部或部分结肠切除术，但用于确定受影响结肠部分的测试是不精确或繁琐的。近年来，我们发展了肠管生理学和病理生理学。7,8可压缩的Fecobionics探针可测量排便过程中的多种压力、方向、肛门直肠角度和形状变化。7,8本研究首次将仿生学应用于结肠运动和运输功能的机制研究。据我们所知，我们确定了从未在体内报道过的新型结肠收缩模式。3
Transport of colonic content is a complex physiologic process through which contents are received from the ileum, solidify during colonic passage, and are finally expelled from the rectum through the anus. 1, 2 Colonic motility and transit are difficult to study where the mechanical loading and motion need to be quantified. Since the classic radiographic work of Cannon in 1902, it has been known that antiperistalsis is a common feature of colonic motility. More recently, the underlying slow wave patterns generated by the interstitial cells of Cajal and ripples on spatiotemporal diameter maps have been described in vitro. 3 Many aspects of colonic motility are still unexplored because of lack of technology to measure physiologic and pathophysiologic processes. Pathophysiologically, constipation affects up to 25% of the population but remains poorly recognized and treated. 4, 5 It is important to distinguish between slow-transit constipation and obstructed defecation. 6 Patients with severe slow-transit constipation may be eligible for total or partial colon resection, but tests for identifying the segments of colon being affected are imprecise or cumbersome. Recently, we developed Fecobionics for studying anorectal physiology and pathophysiology. 7, 8 The compressible Fecobionics probe measures multiple pressures, orientation, anorectal angle, and shape changes during defecation. 7, 8 For the first time here, we advance the use of Fecobionics to the colon for mechanistic studies of colonic motility and transport function. We identify novel colonic contraction patterns never before reported in vivo, to our knowledge. 3
登录
查看更多内容
影响因子：
29.4
作者：
Rao, Satish S. C.;Bharucha, Adil E.;Wald, Arnold
通讯作者：
Wald, Arnold
影响因子：
65.1
作者：
Corsetti, Maura;Costa, Marcello;Tack, Jan
通讯作者：
Tack, Jan
影响因子：
29.4
作者：
Bharucha, Adil E.;Wald, Arnold;Rao, Satish
通讯作者：
Rao, Satish
影响因子：
3.6
作者：
Gregersen, Hans;Chen, Ssu-Chi;Futaba, Kaori
通讯作者：
Futaba, Kaori
DOI：
10.1007/s11938-007-0015-1
发表时间：
2007-06-01
期刊：
Current treatment options in gastroenterology
影响因子：
--
作者：
Feyen, Bryan J;Rao, Satish S C
通讯作者：
Rao, Satish S C