Postoperative Delirium in Neurosurgical Patients: Recent Insights into the Pathogenesis.

Postoperative Delirium in Neurosurgical Patients: Recent Insights into the Pathogenesis.
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神经外科患者术后谵妄:发病机制的最新见解。

DOI:
10.3390/brainsci12101371
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发表时间:
2022-10-09
期刊:
影响因子:
3.3
通讯作者:
Lin, Guozhong
Lin, Guozhong
中科院分区:
医学4区
文献类型:
--
作者:
Xu, Yinuo;Ma, Qianquan;Du, Haiming;Yang, Chenlong;Lin, Guozhong

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术后谵妄(POD)是一种并发症,其特征是手术后或麻醉后不久发生的注意力、意识和认知功能障碍。由于它好发于神经外科患者,对患者的健康构成极大的威胁,因此在神经外科病房中对POD给予了很大的重视。然而,关于其发病机制存在复杂的理论和有限的药物干预。本文主要根据近5年来的研究成果,对POD发病机制的研究进展进行综述,并对POD发展的5种主要病理学说进行总结,以期加深对POD的认识,促进其临床治疗。
Postoperative delirium (POD) is a complication characterized by disturbances in attention, awareness, and cognitive function that occur shortly after surgery or emergence from anesthesia. Since it occurs prevalently in neurosurgical patients and poses great threats to the well-being of patients, much emphasis is placed on POD in neurosurgical units. However, there are intricate theories about its pathogenesis and limited pharmacological interventions for POD. In this study, we review the recent insights into its pathogenesis, mainly based on studies within five years, and the five dominant pathological theories that account for the development of POD, with the intention of furthering our understanding and boosting its clinical management.
DOI: 10.1093/neuros/nyx606
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影响因子: 4.8
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