Roles of β-Endorphin in Stress, Behavior, Neuroinflammation, and Brain Energy Metabolism.
Roles of β-Endorphin in Stress, Behavior, Neuroinflammation, and Brain Energy Metabolism.
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DOI：
10.3390/ijms22010338
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发表时间：
2020-12-30
影响因子：
5.6
通讯作者：
Huang X
中科院分区：
文献类型：
--
作者：
Pilozzi A;Carro C;Huang X
β-内啡肽是一种在全身发挥多种作用的肽。 β-内啡肽通过裂解阿片黑皮素原 (POMC) 产生，是 mu 阿片受体的主要激动剂，这种受体遍布全身、大脑和调节多种系统的免疫系统细胞。作为人体阿片受体的激动剂，β-内啡肽以其强大的镇痛作用而闻名，但除其他作用外，它们还参与以奖励为中心的行为和恢复体内平衡的行为。这些作用表明该肽与精神疾病和神经退行性疾病有关，使其成为人们感兴趣的研究目标。这篇综述简要总结了内啡肽功能的基础知识，回顾了它所控制的行为和调节途径，并检查了正常个体和疾病/紊乱影响个体之间观察到的 β-内啡肽水平的变异性。
β-Endorphins are peptides that exert a wide variety of effects throughout the body. Produced through the cleavage pro-opiomelanocortin (POMC), β-endorphins are the primarily agonist of mu opioid receptors, which can be found throughout the body, brain, and cells of the immune system that regulate a diverse set of systems. As an agonist of the body’s opioid receptors, β-endorphins are most noted for their potent analgesic effects, but they also have their involvement in reward-centric and homeostasis-restoring behaviors, among other effects. These effects have implicated the peptide in psychiatric and neurodegenerative disorders, making it a research target of interest. This review briefly summarizes the basics of endorphin function, goes over the behaviors and regulatory pathways it governs, and examines the variability of β-endorphin levels observed between normal and disease/disorder affected individuals.
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