Survivin expression and its clinical significance in pancreatic cancer.
Survivin expression and its clinical significance in pancreatic cancer.
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DOI：
10.1186/1471-2407-5-127
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发表时间：
2005-10-04
期刊：
影响因子：
3.8
通讯作者：
Kim SN
中科院分区：
文献类型：
--
作者：
Lee MA;Park GS;Lee HJ;Jung JH;Kang JH;Hong YS;Lee KS;Kim DG;Kim SN
Survivin是一种细胞凋亡抑制剂，在几种人类癌症中表达。已知其表达与不良临床预后相关，但在胰腺癌中尚未广泛研究。我们进行这项研究是为了确定胰腺癌中survivin的表达及其作为预后因素的临床意义。我们对来自49个胰腺组织的福尔马林固定石蜡包埋块进行了survivin、p53和Bax的免疫组织化学染色。为了确定与临床病程的关系，我们回顾了患者的临床记录。49例胰腺癌中，46例（93.9%）survivin表达阳性。survivin的表达与p53或bax无显著相关性。在临床病理参数上，survivin阳性患者以神经周围浸润多见，survivin阴性患者以静脉浸润多见（p值分别为0.041和0.040）。低survivin表达的患者对化疗的反应似乎稍好一些。Survivin的表达可能与静脉或神经周围浸润有关，提示转移途径，似乎有可能作为化疗的预测标志物。survivin在胰腺癌中表达的临床意义有待进一步的大规模研究。
Survivin, an inhibitor of apoptosis is expressed in several human cancers. Its expression is known to be associated with poor clinical outcome, but not widely studied in pancreatic cancer. We performed this study to determine the survivin expression in pancreatic cancer and its clinical significance as a prognostic factor. We performed immunohistochemical staining for survivin, p53, and Bax in formalin-fixed, paraffin-embedded block from forty-nine pancreatic tissues. To determine the association with clinical course, we reviewed the patients' clinical record. Of the 49 cases of pancreatic cancer, 46 cases (93.9%) were positive for survivin expression. There was no significant association between survivin expression and p53 or bax. For clinicopathological parameters, perineural invasion was more common in survivin positive and venous invasion was more common in survivin negative (p = 0.041 and 0.040, respectively). Responsiveness to chemotherapy appeared to be slightly better in patients with low survivin expression. Survivin expression may be associated with venous or perineural invasion, indicating metastatic route, and seems to have a potential as a predictive marker for chemotherapy. Further study of large scale is required to determine the clinical significance of survivin expression in pancreatic cancer.
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DOI：
10.1111/j.1349-7006.2002.tb02483.x
发表时间：
2002-09
期刊：
Japanese journal of cancer research : Gann
影响因子：
--
作者：
Asanuma K;Kobayashi D;Furuya D;Tsuji N;Yagihashi A;Watanabe N
通讯作者：
Watanabe N
影响因子：
8
作者：
Islam, A;Kageyama, H;Nakagawara, A
通讯作者：
Nakagawara, A
影响因子：
8.8
作者：
Tonini, G;Vincenzi, B;Picciocchi, A
通讯作者：
Picciocchi, A
影响因子：
2.9
作者：
Nio, Y;Iguchi, C;Tamura, K
通讯作者：
Tamura, K
影响因子：
8.8
作者：
Sarela, A I;Verbeke, C S;Ramsdale, J;Davies, C L;Markham, A F;Guillou, P J
通讯作者：
Guillou, P J