Treatment effects on pain catastrophizing and cutaneous allodynia symptoms in women with migraine and overweight/obesity.
Treatment effects on pain catastrophizing and cutaneous allodynia symptoms in women with migraine and overweight/obesity.
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DOI：
10.1037/hea0000920
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发表时间：
2020-10
期刊：
影响因子：
--
通讯作者：
Bond DS
中科院分区：
文献类型：
--
作者：
Farris SG;Thomas JG;Kibbey MM;Pavlovic JM;Steffen KJ;Bond DS
疼痛灾难化和皮肤异常性疼痛是导致头痛相关残疾的两个危险因素。然而，对于这些危险因素可改变的程度以及非药物治疗相关变化是否与偏头痛改善相关的知识有限。使用来自女性健康和偏头痛（WHAM）的数据，这是一项随机对照试验，比较了行为减肥（BWL）和偏头痛教育（ME）对偏头痛和超重/肥胖女性的影响，我们测试了是否：（a）在治疗后和随访时间点，BWL与ME相比，疼痛灾难性和异常性疼痛相对于基线的变化更大，以及（B）这些改善是否与头痛残疾的改善有关。女性（n = 110）被随机分配到16周的BWL或ME，并在基线、治疗后和随访（32周）时进行评估。多水平混合效应模型测试：（a）随时间推移疼痛灾难化和异常性疼痛变化的组间差异，和（B）疼痛灾难化和异常性疼痛变化与头痛残疾变化的相关性，调整偏头痛严重程度和体重减轻。从基线到治疗后和随访，BWL和ME在疼痛灾难性和异常性疼痛方面均显著降低，并且在不同条件下的改善相当。即使控制了偏头痛和体重减轻的干预相关改善，疼痛灾难化和皮肤异常性疼痛的减少与头痛残疾的显著减少相关。疼痛的灾难性和异常性疼痛不仅减少后，非药物治疗偏头痛，但更大的改善与头痛相关的残疾，独立于偏头痛的严重程度。
Pain catastrophizing and cutaneous allodynia represent two risk factors for greater headache-related disability. Yet, there is limited knowledge of the extent to which these risk factors are modifiable and whether non-pharmacological treatment-related changes are associated with migraine improvements. Using data from the Women’s Health and Migraine (WHAM), a randomized controlled trial that compared effects of behavioral weight loss (BWL) and migraine education (ME) in women with migraine and overweight/obesity, we tested whether: (a) BWL v ME produced greater changes in pain catastrophizing and allodynia from baseline across post-treatment and follow-up time points and (b) whether these improvements were associated with improvements in headache disability. Women (n = 110) were randomly assigned to 16 weeks of either BWL or ME and assessed at baseline, post-treatment, and follow-up (32 weeks). Multilevel mixed effects modeling tested: (a) for between-group differences in pain catastrophizing and allodynia changes over time, and (b) associations of changes in pain catastrophizing and allodynia with changes in headache disability, adjusting for migraine severity and weight loss. Both BWL and ME had significant reductions in pain catastrophizing and allodynia from baseline to post-treatment and follow-up, and the improvements were comparable across conditions. Reductions in pain catastrophizing and cutaneous allodynia were associated with significant reductions in headache disability, even when controlling for intervention-related improvements in migraine and weight loss. Pain catastrophizing and allodynia are not only reduced after non-pharmacologic treatments for migraine, but greater improvements are associated with greater reductions in headache-related disability, independent of migraine severity.
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影响因子：
3.7
作者：
Oshinsky, Michael L
通讯作者：
Oshinsky, Michael L
影响因子：
5
作者：
Bond DS;Buse DC;Lipton RB;Thomas JG;Rathier L;Roth J;Pavlovic JM;Evans EW;Wing RR
通讯作者：
Wing RR
影响因子：
5
作者：
Dodick, David;Silberstein, Stephen
通讯作者：
Silberstein, Stephen
DOI：
10.1186/s10194-017-0748-8
发表时间：
2017-12
期刊：
The journal of headache and pain
影响因子：
--
作者：
Galioto R;O'Leary KC;Thomas JG;Demos K;Lipton RB;Gunstad J;Pavlović JM;Roth J;Rathier L;Bond DS
通讯作者：
Bond DS
影响因子：
11.2
作者：
Burstein, R;Collins, B;Jakubowski, M
通讯作者：
Jakubowski, M