HIV cure research in the time of COVID-19 - Antiretroviral therapy treatment interruption trials: A discussion paper.
HIV cure research in the time of COVID-19 - Antiretroviral therapy treatment interruption trials: A discussion paper.
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DOI：
10.1016/j.jve.2020.100025
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发表时间：
2021-03
影响因子：
5.5
通讯作者：
Frater J
中科院分区：
文献类型：
--
作者：
Fidler S;Lewin S;Deeks S;Sogaard OS;Vanderkerckhove L;Collins S;Kelly D;Singh J;Caskey M;Frater J
本讨论文件讨论了艾滋病毒治愈研究的安全性，特别是那些涉及停止抗逆转录病毒治疗的研究，在SARS-CoV-2大流行的背景下称为分析性治疗中断（ATI）。ClinicalTrials.gov上列出的30多项研究包括ATI，许多其他研究计划在未来12个月内开始，但大多数都因COVID-19大流行而停止。我们认为，在重新启动HIV治愈临床试验之前，应考虑伦理、风险和实际考虑因素，并注意到ATI在传播SARS-CoV-2的背景下的特定风险。
This discussion paper addresses the safety of HIV cure studies, particularly those involving stopping antiretroviral therapy, known as an analytic treatment interruption (ATI) in the context of the SARS-CoV-2 pandemic. More than 30 studies listed on ClinicalTrials.gov include an ATI and many others were planned to begin over the next 12 months but most were halted due to the COVID-19 pandemic. We consider the ethics, risks and practical considerations to be taken into account before re-opening HIV cure clinical trials, noting the specific risks of ATI in the context of circulating SARS-CoV-2.
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影响因子：
4.6
作者：
Fidler S;Lewis H;Meyerowitz J;Kuldanek K;Thornhill J;Muir D;Bonnissent A;Timson G;Frater J
通讯作者：
Frater J
影响因子：
5.4
作者：
Chen, Wen-Hsiang;Strych, Ulrich;Bottazzi, Maria Elena
通讯作者：
Bottazzi, Maria Elena
DOI：
10.1073/pnas.94.24.13193
发表时间：
1997-11-25
影响因子：
11.1
作者：
Chun, TW;Stuyver, L;Fauci, AS
通讯作者：
Fauci, AS
影响因子：
39.2
作者：
del Amo, Julia;Polo, Rosa;Hernan, Miguel A.
通讯作者：
Hernan, Miguel A.
影响因子：
6
作者：
Church K;Machiyama K;Todd J;Njamwea B;Mwangome M;Hosegood V;Michel J;Oti S;Nyamukapa C;Crampin A;Amek N;Nakigozi G;Michael D;Gómez-Olivé FX;Nakiyingi-Miiro J;Zaba B;Wringe A
通讯作者：
Wringe A