Apnea in acute bilirubin encephalopathy.
Apnea in acute bilirubin encephalopathy.
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DOI:
10.1053/j.semperi.2014.08.003
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发表时间:
2014-11
影响因子:
3.4
通讯作者:
Watchko JF
中科院分区:
文献类型:
--
作者:
Amin SB;Bhutani VK;Watchko JF
Central apnea, defined as cessation of breathing for ≥ 20 seconds, is frequent in premature infants born < 34 weeks gestation but uncommon among healthy late preterm (340/7 – 366/7 weeks gestation) and term (≥ 37 weeks gestation) infants where it is usually a clinical manifestation of a neurological or metabolic problem. There is growing evidence that marked unconjugated hyperbilirubinemia is associated with central apnea in neonates. This paper explores the reported association between acute bilirubin encephalopathy and symptomatic apneic events in newborns and the possible mechanisms involved in the pathogenesis of this phenomenon. The prevalence of symptomatic apneic events in reports of acute bilirubin encephalopathy suggests this clinical finding should be considered a sign of bilirubin neurotoxicity.
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RESPIRATION PHYSIOLOGY
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