Dietary intake of branched-chain amino acids and survival after colorectal cancer diagnosis.
Dietary intake of branched-chain amino acids and survival after colorectal cancer diagnosis.
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DOI：
10.1002/ijc.33449
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发表时间：
2021-05-15
影响因子：
6.4
通讯作者：
Zhang X
中科院分区：
文献类型：
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作者：
Long L;Yang W;Liu L;Tobias DK;Katagiri R;Wu K;Jin L;Zhang FF;Luo X;Liu X;Ogino S;Chan AT;Meyerhardt JA;Giovannucci E;Zhang X
支链氨基酸（BCAAs），包括亮氨酸、异亮氨酸和缬氨酸，可能通过多种机制潜在地影响癌症的进展，包括其在胰岛素抵抗中的作用。然而，BCAAs与结直肠癌（CRC）患者生存的关系尚不清楚。我们在护士健康研究和卫生专业人员随访研究中评估了1,674名非转移性结直肠癌患者诊断后BCAA摄入量与CRC特异性和总体死亡率之间的关系。患者完成了一份有效的食物频率问卷。在调整肿瘤特征和潜在混杂因素后，采用Cox比例风险回归模型计算多变量风险比（hr）。比较诊断后总BCAA的最高和最低四分位数摄入量，crc特异性死亡率的多变量hr为1.18[95%可信区间（CI）， 0.75-1.85, Ptrend=0.46]，全因死亡率的多变量hr为1.30 （95% CI, 1.01-1.69, Ptrend=0.04）。未观察到每种BCAA摄入量与crc特异性死亡率有统计学意义的关联（p趋势均为0.30）。然而，缬氨酸全因死亡率的多变量hr（最高四分位数vs最低四分位数）为1.33 (95% CI, 1.03-1.73, Ptrend=0.02)，亮氨酸为1.28 (95% CI, 0.99-1.66, Ptrend=0.05)，异亮氨酸为1.25 （95% CI, 0.96-1.61, Ptrend=0.06）。我们的研究结果表明，CRC患者饮食中摄入更多的支链氨基酸与全因死亡风险之间存在正相关。这些发现有待证实，这种关联的潜在机制有待阐明。
Branched chain amino acids (BCAAs), including leucine, isoleucine, and valine, may potentially influence cancer progression by various mechanisms including its role in insulin resistance. However, the association of BCAAs with survival among patients with established colorectal cancer (CRC) remains unclear. We evaluated the associations between postdiagnostic BCAA intake with CRC-specific and overall-mortality among 1,674 patients with nonmetastatic CRC in the Nurses’ Health Study and the Health Professionals Follow-up Study. Patients completed a validated food frequency questionnaire. Multivariable hazard ratios (HRs) were calculated using Cox proportional hazards regression model after adjustment for tumor characteristics and potential confounding factors. Comparing the highest with the lowest quartile intake of postdiagnostic total BCAA, the multivariable HRs were 1.18 [95% confidence interval (CI), 0.75–1.85, Ptrend=0.46 across quartiles] for CRC-specific mortality and 1.30 (95% CI, 1.01–1.69, Ptrend=0.04) for all-cause mortality. No statistically significant associations with each of the BCAA intake were observed for CRC-specific mortality (all Ptrend>0.30). However, the multivariable HRs (the highest vs. the lowest quartile) for all-cause mortality were 1.33 (95% CI, 1.03–1.73, Ptrend=0.02) for valine, 1.28 (95% CI, 0.99–1.66, Ptrend=0.05) for leucine, and 1.25 (95% CI, 0.96–1.61, Ptrend=0.06) for isoleucine. Our findings suggest a positive associations between higher intake of dietary BCAAs and risk of all-cause mortality in CRC patients. These findings need to be confirmed and potential mechanisms underlying this association need to be elucidated.
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作者：
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通讯作者：
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