An overview of amines as nutritional supplements to counteract cancer cachexia.
An overview of amines as nutritional supplements to counteract cancer cachexia.
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DOI：
10.1007/s13539-014-0138-x
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发表时间：
2014-06
影响因子：
8.9
通讯作者：
Lancha, Antonio Herbert, Jr.
中科院分区：
文献类型：
--
作者：
de Campos-Ferraz, Patricia Lopes;Andrade, Isabel;das Neves, Willian;Hangai, Isabela;Rodrigues Alves, Christiano Robles;Lancha, Antonio Herbert, Jr.
癌症恶病质是一种复杂的多因素综合征，其特征是骨骼肌质量损失（伴或不伴脂肪质量损失），常规营养支持无法完全逆转，并导致进行性功能障碍。近年来，一些氨基酸和其他胺类膳食补充剂由于对骨骼肌萎缩疾病的积极作用而在医学领域受到重视。因此，这篇简短的综述的目的是讨论胺作为膳食补充剂对抗癌症恶病质骨骼肌消耗的假定应用。具体来说，我们专注于两种营养补充剂：（1）支链氨基酸（BCAAs）和（2）肌酸。支链氨基酸和肌酸都可以减弱骨骼肌中蛋白质的水解，促进蛋白质的合成。虽然更多的实验研究和临床试验仍然需要阐明这种治疗应用，一些证据表明，胺补充剂是一个有前途的辅助治疗癌症恶病质。
Cancer cachexia is a complex multifactorial syndrome characterized by loss of skeletal muscle mass (with or without loss of fat mass) that cannot be fully reversed by conventional nutritional support and leads to progressive functional impairment. Recently, some amino acids and other amine dietary supplements have been highlighted in medical field due to positive effects upon diseases evolving skeletal muscle atrophy. Therefore, the aim of this brief review is to discuss the putative application of amines as dietary supplements to counteract skeletal muscle wasting on cancer cachexia. Specifically, we focus in two nutritional supplements: (1) branched-chain amino acids (BCAAs) and (2) creatine. Both BCAAs and creatine may attenuate proteolysis and enhance proteins synthesis in skeletal muscle. Although more experimental studies and clinical trials are still necessary to elucidate this therapeutic application, several evidences have demonstrated that amines supplementation is a promising coadjuvant treatment to cancer cachexia.
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影响因子：
4.4
作者：
Campos-Ferraz, Patricia L.;Bozza, Thomas;Lancha, Antonio Herbert, Jr.
通讯作者：
Lancha, Antonio Herbert, Jr.
影响因子：
4.2
作者：
Peters, S. J.;Van Helvoort, A.;Van Norren, K.
通讯作者：
Van Norren, K.
DOI：
10.1007/bf02470093
发表时间：
1985-01-01
期刊：
JAPANESE JOURNAL OF SURGERY
影响因子：
--
作者：
KAWAMURA, I;SATO, H;BLACKBURN, GL
通讯作者：
BLACKBURN, GL
影响因子：
5.4
作者：
Patra, Subrata;Bera, Soumen;Ray, Manju
通讯作者：
Ray, Manju
影响因子：
2.2
作者：
Nicastro H;da Luz CR;Chaves DF;Bechara LR;Voltarelli VA;Rogero MM;Lancha AH Jr
通讯作者：
Lancha AH Jr