Longitudinal brain volume changes in preterm and term control subjects during late childhood and adolescence.
Longitudinal brain volume changes in preterm and term control subjects during late childhood and adolescence.
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DOI：
10.1542/peds.2008-0025
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发表时间：
2009-02
期刊：
影响因子：
8
通讯作者：
Reiss AL
中科院分区：
文献类型：
--
作者：
Ment LR;Kesler S;Vohr B;Katz KH;Baumgartner H;Schneider KC;Delancy S;Silbereis J;Duncan CC;Constable RT;Makuch RW;Reiss AL
尽管早产儿极低出生体重儿在同等年龄段进行评估时，神经解剖异常的发生率很高，但早产儿在学龄期和青春期的大脑发育模式仍然很不清楚。我们的目标是验证早产会导致发育中的大脑发生长期动态变化的假设。我们在8岁和12岁时对55名出生体重在600到1250克的早产儿和20名足月对照组儿童进行了一系列的容量磁共振研究，他们参与了一项前瞻性、随机、安慰剂对照的脑室内出血预防研究的后续部分。早产儿和足月儿在8岁到12岁之间的总脑体积增加了2%到3%。这些变化包括大脑灰质的减少，而脑白质的增加。在8到12岁之间，早产儿的左侧大脑灰质减少了2%，而足月对照组的左侧大脑灰质减少了10%。对于右侧大脑灰质，早产儿在8到12岁之间经历了3%的体积减少，而足月儿对照组(按时间分组)的体积减少了9%。相比之下，早产儿在8至12岁之间双侧脑白质体积增加了10%，而足月对照组的双侧大脑半球增加了26%。在研究组之间，双侧颞叶灰质和顶叶白质的区域体积变化有显著差异。在有早产儿的儿童晚期和青春期早期，早产继续扰乱大脑发育的轨迹，表现出与足月对照组受试者相比，随着时间的推移，灰质减少和白质增加都较少。
Although preterm very low birth weight infants have a high prevalence of neuroanatomical abnormalities when evaluated at term-equivalent age, patterns of brain growth in prematurely born infants during school age and adolescence remain largely unknown. Our goal was to test the hypothesis that preterm birth results in long-term dynamic changes in the developing brain. We performed serial volumetric MRI studies at ages 8 and 12 years in 55 preterm infants born weighing 600 to 1250 g and 20 term control children who participated in the follow-up component of a prospective, randomized, placebo-controlled intraventricular hemorrhage prevention study. Total brain volumes increased 2% to 3% between the ages of 8 and 12 years for both preterm and term children. These changes involved reductions in cerebral gray matter while white matter increased. Between 8 and 12 years of age, preterm subjects experienced a 2% decrease in left cerebral gray matter compared with a 10% reduction in left cerebral gray for term controls. For right cerebral gray matter, preterm children experienced a 3% decrease in volume between years 8 and 12, compared with 9% for term controls (group-by-time). In contrast, preterm subjects had a 10% increase in cerebral white matter volumes bilaterally between ages 8 and 12 years, compared with >26% increases for both hemispheres for term controls. Significant differences in regional volume changes between study groups were found in bilateral temporal gray and in parietal white matter. Preterm birth continues to perturb the trajectory of cerebral development during late childhood and early adolescence with preterm children, showing both lower gray matter reduction and less white matter gain over time compared with term control subjects.
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影响因子：
3
作者：
Counsell, SJ;Boardman, JP
通讯作者：
Boardman, JP
影响因子：
3.8
作者：
Allin, M;Henderson, M;Murray, R
通讯作者：
Murray, R
DOI：
10.1097/00004583-200109000-00009
发表时间：
2001-09-01
影响因子：
13.3
作者：
Durston, S;Pol, HEH;van Engeland, H
通讯作者：
van Engeland, H
影响因子：
8
作者：
Lodygensky, GA;Rademaker, K;Huppi, PS
通讯作者：
Huppi, PS
影响因子：
14.5
作者：
Nosarti, Chiara;Giouroukou, Elena;Murray, Robin M.
通讯作者：
Murray, Robin M.