Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease.
Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease.
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DOI：
10.1126/science.1247391
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发表时间：
2014-08-22
期刊：
影响因子：
--
通讯作者：
Trucco M
中科院分区：
文献类型：
--
作者：
Fox IJ;Daley GQ;Goldman SA;Huard J;Kamp TJ;Trucco M
源自患者的多能干细胞（PSC）定向分化为各种细胞类型，有望成为治疗多种疾病的原材料。精确分化的PSC衍生细胞的可获得性将极大地影响血液成分和造血干细胞疗法，并应有助于糖尿病、某些肝病和神经系统疾病、视网膜疾病以及可能的心脏病的治疗。尽管需要无限供应特定的细胞类型，但还必须克服其他障碍。这篇对细胞疗法现状的综述强调了重要的挑战。成功的细胞移植将需要优化最佳的细胞类型和植入部位，克服细胞迁移和组织整合的限制，并且有时需要控制免疫反应性。科学家、临床医生和企业之间的合作对于开发新的基于干细胞的疗法至关重要。
Patient-derived pluripotent stem cells (PSC) directed to various cell fates holds promise as source material for treating numerous disorders. The availability of precisely differentiated PSC-derived cells will dramatically impact blood component and hematopoietic stem cell therapies, and should facilitate treatment of diabetes, some forms of liver disease and neurologic disorders, retinal diseases, and possibly heart disease. Although an unlimited supply of specific cell types are needed, other barriers must be overcome. This review of the state of cell therapies highlights important challenges. Successful cell transplantation will require optimizing the best cell type and site for engraftment, overcoming limitations to cell migration and tissue integration, and occasionally needing to control immunologic reactivity. Collaboration among scientists, clinicians, and industry is critical for generating new stem cell-based therapies.
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影响因子：
7.7
作者：
Creusot RJ;Giannoukakis N;Trucco M;Clare-Salzler MJ;Fathman CG
通讯作者：
Fathman CG
影响因子：
24
作者：
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通讯作者：
Gepstein, Lior
影响因子：
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作者：
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Cossu, G
影响因子：
15.9
作者：
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通讯作者：
MINTZ, DH
影响因子：
21.3
作者：
Dellavalle, Arianna;Sampaolesi, Maurilio;Cossu, Giulio
通讯作者：
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